PDB: 82203 件ウェブページステータス検索Chemie searchBIRD

---

1NL9	Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Compound 12 Using a Linked-Fragment Strategy 分子名称: 2-{[4-(2-ACETYLAMINO-2-PENTYLCARBAMOYL-ETHYL)-NAPHTHALEN-1-YL]-OXALYL-AMINO}-BENZOIC ACID, Protein-tyrosine phosphatase, non-receptor type 1 著者 Szczepankiewicz, B.G, Liu, G, Hajduk, P.J, Abad-Zapatero, C, Pei, Z, Xin, Z, Lubben, T, Trevillyan, J.M, Stashko, M.A, Ballaron, S.J, Liang, H, Huang, F, Hutchins, C.W, Fesik, S.W, Jirousek, M.R. 登録日 2003-01-06 公開日 2003-04-08 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy J.Am.Chem.Soc., 125, 2003
3ITM	Catalytic domain of hPDE2A 分子名称: ZINC ION, cGMP-dependent 3',5'-cyclic phosphodiesterase 著者 Pandit, J. 登録日 2009-08-28 公開日 2009-10-27 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct. Proc.Natl.Acad.Sci.USA, 106, 2009
1EZF	CRYSTAL STRUCTURE OF HUMAN SQUALENE SYNTHASE 分子名称: FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE, N-{2-[TRANS-7-CHLORO-1-(2,2-DIMETHYL-PROPYL) -5-NAPHTHALEN-1-YL-2-OXO-1,2,3,5-TETRAHYDRO-BENZO[E] [1,4]OXAZEPIN-3-YL]-ACETYL}-ASPARTIC ACID 著者 Pandit, J, Danley, D.E, Schulte, G.K, Mazzalupo, S.M, Pauly, T.A, Hayward, C.M, Hamanaka, E.S, Thompson, J.F, Harwood, H.J. 登録日 2000-05-10 公開日 2000-10-18 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis. J.Biol.Chem., 275, 2000
1OZF	The crystal structure of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactors 分子名称: Acetolactate synthase, catabolic, DI(HYDROXYETHYL)ETHER, ... 著者 Pang, S.S, Duggleby, R.G, Schowen, R.L, Guddat, L.W. 登録日 2003-04-09 公開日 2003-11-11 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The Crystal Structures of Klebsiella pneumoniae Acetolactate Synthase with Enzyme-bound Cofactor and with an Unusual Intermediate. J.Biol.Chem., 279, 2004
6ELC	Crystal Structure of O-linked Glycosylated VSG3 分子名称: Variant surface glycoprotein, alpha-D-glucopyranose, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Stebbins, C.E. 登録日 2017-09-28 公開日 2018-07-11 最終更新日 2022-03-30 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat. Nat Microbiol, 3, 2018
1OZH	The crystal structure of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate. 分子名称: 2-HYDROXYETHYL DIHYDROTHIACHROME DIPHOSPHATE, Acetolactate synthase, catabolic, ... 著者 Pang, S.S, Duggleby, R.G, Schowen, R.L, Guddat, L.W. 登録日 2003-04-09 公開日 2003-11-04 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Crystal Structures of Klebsiella pneumoniae Acetolactate Synthase with Enzyme-bound Cofactor and with an Unusual Intermediate. J.Biol.Chem., 279, 2004
1BM3	IMMUNOGLOBULIN OPG2 FAB-PEPTIDE COMPLEX 分子名称: IMMUNOGLOBULIN OPG2 FAB, CONSTANT DOMAIN, VARIABLE DOMAIN 著者 Kodandapani, R, Veerapandian, L, Ni, C.Z, Chiou, C.-K, Whital, R, Kunicki, T.J, Ely, K.R. 登録日 1999-04-15 公開日 1999-04-20 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Conformational change in an anti-integrin antibody: structure of OPG2 Fab bound to a beta 3 peptide. Biochem.Biophys.Res.Commun., 251, 1998
5Q1S	PanDDA analysis group deposition -- Crystal Structure of DCLRE1A in complex with BDOOA011525c 分子名称: DNA cross-link repair 1A protein, MALONATE ION, NICKEL (II) ION, ... 著者 Newman, J.A, Aitkenhead, H, Lee, S.Y, Kupinska, K, Burgess-Brown, N, Tallon, R, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. 登録日 2017-05-15 公開日 2018-08-08 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 PanDDA analysis group deposition To Be Published
5Q1X	PanDDA analysis group deposition -- Crystal Structure of DCLRE1A in complex with FMOPL000085a 分子名称: 2,4-bis(fluoranyl)-6-(1~{H}-pyrazol-3-yl)phenol, DNA cross-link repair 1A protein, MALONATE ION, ... 著者 Newman, J.A, Aitkenhead, H, Lee, S.Y, Kupinska, K, Burgess-Brown, N, Tallon, R, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. 登録日 2017-05-15 公開日 2018-08-08 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 PanDDA analysis group deposition To Be Published
3ITU	hPDE2A catalytic domain complexed with IBMX 分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, MAGNESIUM ION, ZINC ION, ... 著者 Pandit, J. 登録日 2009-08-28 公開日 2009-10-27 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct. Proc.Natl.Acad.Sci.USA, 106, 2009
3I9S	Structure from the mobile metagenome of V.cholerae. Integron cassette protein VCH_CASS6 分子名称: CHLORIDE ION, Integron cassette protein, SULFATE ION 著者 Deshpande, C.N, Sureshan, V, Harrop, S.J, Boucher, Y, Xu, X, Cui, H, Edwards, A, Savchenko, A, Joachimiak, A, Chang, C, Stokes, H.W, Curmi, P.M.G, Mabbutt, B.C, Midwest Center for Structural Genomics (MCSG) 登録日 2009-07-13 公開日 2009-08-11 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure from the mobile metagenome of V.cholerae. Integron cassette protein VCH_CASS6 To be Published
1JSC	Crystal Structure of the Catalytic Subunit of Yeast Acetohydroxyacid Synthase: A target for Herbicidal Inhibitors 分子名称: ACETOHYDROXY-ACID SYNTHASE, DIHYDROGENPHOSPHATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Pang, S.S, Duggleby, R.G, Guddat, L.W. 登録日 2001-08-17 公開日 2002-01-16 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors. J.Mol.Biol., 317, 2002
3JWO	Structure of HIV-1 gp120 with gp41-Interactive Region: Layered Architecture and Basis of Conformational Mobility 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB 48D Heavy CHAIN, FAB 48D LIGHT CHAIN, ... 著者 Pancera, M, Majeed, S, Huang, C.C, Kwon, Y.D, Zhou, T, Robinson, J.E, Sodroski, J, Wyatt, R, Kwong, P.D. 登録日 2009-09-18 公開日 2009-12-29 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.51 Å) 主引用文献 Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility. Proc.Natl.Acad.Sci.USA, 107, 2010
1S01	LARGE INCREASES IN GENERAL STABILITY FOR SUBTILISIN BPN(PRIME) THROUGH INCREMENTAL CHANGES IN THE FREE ENERGY OF UNFOLDING 分子名称: CALCIUM ION, ISOPROPYL ALCOHOL, Subtilisin BPN' 著者 Whitlow, M, Howard, A.J, Wood, J.F. 登録日 1989-08-21 公開日 1990-10-15 最終更新日 2018-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Large increases in general stability for subtilisin BPN' through incremental changes in the free energy of unfolding. Biochemistry, 28, 1989
1NZJ	Crystal Structure and Activity Studies of Escherichia Coli Yadb ORF 分子名称: Hypothetical protein yadB, ZINC ION 著者 Campanacci, V, Kern, D.Y, Becker, H.D, Spinelli, S, Valencia, C, Vincentelli, R, Pagot, F, Bignon, C, Giege, R, Cambillau, C. 登録日 2003-02-18 公開日 2004-04-13 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The Escherichia coli YadB gene product reveals a novel aminoacyl-tRNA synthetase like activity. J.Mol.Biol., 337, 2004
1N8V	Chemosensory Protein in complex with bromo-dodecanol 分子名称: BROMO-DODECANOL, chemosensory protein 著者 Campanacci, V, Lartigue, A, Hallberg, B.M, Jones, T.A, Giudici-Orticoni, M.T, Tegoni, M, Cambillau, C. 登録日 2002-11-21 公開日 2003-04-01 最終更新日 2017-02-01 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Moth chemosensory protein exhibits drastic conformational changes and cooperativity on ligand binding. Proc.Natl.Acad.Sci.USA, 100, 2003
1LLT	BIRCH POLLEN ALLERGEN BET V 1 MUTANT E45S 分子名称: POLLEN ALLERGEN BET V 1 著者 Spangfort, M.D, Mirza, O, Ipsen, H, Van Neerven, R.J, Gajhede, M, Larsen, J.N. 登録日 2002-04-30 公開日 2003-10-28 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Dominating IgE-binding epitope of Bet v 1, the major allergen of birch pollen, characterized by X-ray crystallography and site-directed mutagenesis. J.Immunol., 171, 2003
1OZG	The crystal structure of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate 分子名称: 2-HYDROXYETHYL DIHYDROTHIACHROME DIPHOSPHATE, Acetolactate synthase, catabolic, ... 著者 Pang, S.S, Duggleby, R.G, Schowen, R.L, Guddat, L.W. 登録日 2003-04-09 公開日 2003-11-04 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The Crystal Structures of Klebsiella pneumoniae Acetolactate Synthase with Enzyme-bound Cofactor and with an Unusual Intermediate. J.Biol.Chem., 279, 2004
1GMY	Cathepsin B complexed with dipeptidyl nitrile inhibitor 分子名称: 2-AMINOETHANIMIDIC ACID, 3-METHYLPHENYLALANINE, CATHEPSIN B, ... 著者 Greenspan, P.D, Clark, K.L, Tommasi, R.A, Cowen, S.D, McQuire, L.W, Farley, D.L, van Duzer, J.H, Goldberg, R.L, Zhou, H, Du, Z, Fitt, J.J, Coppa, D.E, Fang, Z, Macchia, W, Zhu, L, Capparelli, M.P, Goldstein, R, Wigg, A.M, Doughty, J.R, Bohacek, R.S, Knap, A.K. 登録日 2001-09-25 公開日 2002-09-19 最終更新日 2017-07-05 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B Through Structure-Based Drug Design J.Med.Chem., 44, 2001
3J9L	Structure of Dark apoptosome from Drosophila melanogaster 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Apaf-1 related killer DARK 著者 Pang, Y, Bai, X, Yan, C, Hao, Q, Chen, Z, Wang, J, Scheres, S.H.W, Shi, Y. 登録日 2015-02-04 公開日 2015-02-25 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila. Genes Dev., 29, 2015
1NNY	Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Compound 23 Using a Linked-Fragment Strategy 分子名称: 3-({5-[(N-ACETYL-3-{4-[(CARBOXYCARBONYL)(2-CARBOXYPHENYL)AMINO]-1-NAPHTHYL}-L-ALANYL)AMINO]PENTYL}OXY)-2-NAPHTHOIC ACID, Protein-tyrosine phosphatase, non-receptor type 1 著者 Szczepankiewicz, B.G, Liu, G, Hajduk, P.J, Abad-Zapatero, C, Pei, Z, Xin, Z, Lubben, T, Trevillyan, J.M, Stashko, M.A, Ballaron, S.J, Liang, H, Huang, F, Hutchins, C.W, Fesik, S.W, Jirousek, M.R. 登録日 2003-01-14 公開日 2003-04-08 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy J.Am.Chem.Soc., 125, 2003
5NI4	Crystal structure of human LTA4H mutant E271A in complex with LTA4 (crystal form II) 分子名称: 5S-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid, IMIDAZOLE, Leukotriene A-4 hydrolase, ... 著者 Stsiapanava, A. 登録日 2017-03-23 公開日 2017-08-23 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.895 Å) 主引用文献 Capturing LTA4 hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB4 synthesis. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
1NO6	Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Compound 5 Using a Linked-Fragment Strategy 分子名称: 2-[(CARBOXYCARBONYL)(1-NAPHTHYL)AMINO]BENZOIC ACID, Protein-tyrosine phosphatase, non-receptor type 1 著者 Szczepankiewicz, B.G, Liu, G, Hajduk, P.J, Abad-Zapatero, C, Pei, Z, Xin, Z, Lubben, T, Trevillyan, J.M, Stashko, M.A, Ballaron, S.J, Liang, H, Huang, F, Hutchins, C.W, Fesik, S.W, Jirousek, M.R. 登録日 2003-01-15 公開日 2003-04-08 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy J.Am.Chem.Soc., 125, 2003
1NPH	Gelsolin Domains 4-6 in Active, Actin Free Conformation Identifies Sites of Regulatory Calcium Ions 分子名称: CALCIUM ION, Gelsolin 著者 Kolappan, S, Gooch, J.T, Weeds, A.G, McLaughlin, P.J. 登録日 2003-01-17 公開日 2003-05-13 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Gelsolin Domains 4-6 in Active, Actin-Free Conformation Identifies Sites of Regulatory Calcium Ions J.Mol.Biol., 329, 2003
5Q1J	PanDDA analysis group deposition -- Crystal Structure of DCLRE1A in complex with FMSOA000341b 分子名称: DNA cross-link repair 1A protein, MALONATE ION, N-(2-hydroxyphenyl)acetamide, ... 著者 Newman, J.A, Aitkenhead, H, Lee, S.Y, Kupinska, K, Burgess-Brown, N, Tallon, R, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. 登録日 2017-05-15 公開日 2018-08-08 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 PanDDA analysis group deposition To Be Published

<113114115116117118119120121122123124125126127128>