3ITU
hPDE2A catalytic domain complexed with IBMX
Summary for 3ITU
| Entry DOI | 10.2210/pdb3itu/pdb |
| Related | 1Z1L 3ITM |
| Descriptor | cGMP-dependent 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
| Functional Keywords | zn-binding, all-alpha-helical, alternative splicing, cgmp, hydrolase, membrane, polymorphism |
| Biological source | Homo sapiens (human) |
| Cellular location | Isoform PDE2A3: Cell membrane ; Lipid-anchor . Isoform PDE2A2: Mitochondrion matrix . Isoform PDE2A1: Cytoplasm . Isoform 5: Mitochondrion : O00408 |
| Total number of polymer chains | 4 |
| Total formula weight | 162148.24 |
| Authors | Pandit, J. (deposition date: 2009-08-28, release date: 2009-10-27, Last modification date: 2024-02-21) |
| Primary citation | Pandit, J.,Forman, M.D.,Fennell, K.F.,Dillman, K.S.,Menniti, F.S. Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct. Proc.Natl.Acad.Sci.USA, 106:18225-18230, 2009 Cited by PubMed: 19828435DOI: 10.1073/pnas.0907635106 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
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