3ITU

hPDE2A catalytic domain complexed with IBMX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity
C	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
C	0007165	biological_process	signal transduction
C	0008081	molecular_function	phosphoric diester hydrolase activity
D	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
D	0007165	biological_process	signal transduction
D	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	HOH6
A	HIS660
A	HIS696
A	ASP697
A	ASP808
A	HOH922

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 920

Chain	Residue
A	HOH5
A	ASP697
A	HOH922
A	HOH2
A	HOH3
A	HOH4

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE IBM A 999

Chain	Residue
A	HOH42
A	TYR655
A	LEU809
A	GLN812
A	ILE826
A	GLN859
A	PHE862
A	HOH1271
A	HOH1704

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN B 2

Chain	Residue
B	HOH7
B	HOH12
B	HIS660
B	HIS696
B	ASP697
B	ASP808

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 920

Chain	Residue
B	HOH7
B	HOH8
B	HOH9
B	HOH10
B	HOH11
B	ASP697

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IBM B 999

Chain	Residue
B	HOH60
B	LEU809
B	GLN812
B	ILE826
B	GLN859
B	PHE862
B	HOH1367

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN C 3

Chain	Residue
C	HOH13
C	HOH18
C	HIS660
C	HIS696
C	ASP697
C	ASP808

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 920

Chain	Residue
C	HOH13
C	HOH14
C	HOH15
C	HOH16
C	HOH17
C	ASP697

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE IBM C 999

Chain	Residue
C	HOH31
C	HIS656
C	LEU809
C	GLN812
C	ILE826
C	GLN859
C	PHE862
C	HOH1720

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN D 4

Chain	Residue
D	HOH19
D	HOH24
D	HIS660
D	HIS696
D	ASP697
D	ASP808

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 920

Chain	Residue
D	HOH19
D	HOH20
D	HOH21
D	HOH22
D	HOH23
D	ASP697

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IBM D 999

Chain	Residue
D	HOH113
D	LEU809
D	GLN812
D	ILE826
D	GLN859
D	PHE862
D	HOH1032

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGtnNsF

Chain	Residue	Details
A	HIS696-PHE707

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15938621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19828435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23899287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JIB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15938621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19828435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23899287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JIB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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