1EZF

CRYSTAL STRUCTURE OF HUMAN SQUALENE SYNTHASE

Summary for 1EZF

Entry DOI	10.2210/pdb1ezf/pdb
Descriptor	FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE, N-{2-[TRANS-7-CHLORO-1-(2,2-DIMETHYL-PROPYL) -5-NAPHTHALEN-1-YL-2-OXO-1,2,3,5-TETRAHYDRO-BENZO[E] [1,4]OXAZEPIN-3-YL]-ACETYL}-ASPARTIC ACID (3 entities in total)
Functional Keywords	isoprenoid synthase fold, all alpha-helix, transferase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein: P37268
Total number of polymer chains	3
Total formula weight	119366.50
Authors	Pandit, J.,Danley, D.E.,Schulte, G.K.,Mazzalupo, S.M.,Pauly, T.A.,Hayward, C.M.,Hamanaka, E.S.,Thompson, J.F.,Harwood, H.J. (deposition date: 2000-05-10, release date: 2000-10-18, Last modification date: 2024-02-07)
Primary citation	Pandit, J.,Danley, D.E.,Schulte, G.K.,Mazzalupo, S.,Pauly, T.A.,Hayward, C.M.,Hamanaka, E.S.,Thompson, J.F.,Harwood Jr., H.J. Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis. J.Biol.Chem., 275:30610-30617, 2000 Cited by PubMed: 10896663 DOI: 10.1074/jbc.M004132200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation