1EZF
CRYSTAL STRUCTURE OF HUMAN SQUALENE SYNTHASE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE | polymer | 340 | 39221.8 | 3 | UniProt (P37268) Pfam (PF00494) | Homo sapiens (human) | SQUALENE SYNTHETASE |
| 2 | D, E, F (A, B, C) | N-{2-[TRANS-7-CHLORO-1-(2,2-DIMETHYL-PROPYL) -5-NAPHTHALEN-1-YL-2-OXO-1,2,3,5-TETRAHYDRO-BENZO[E] [1,4]OXAZEPIN-3-YL]-ACETYL}-ASPARTIC ACID | non-polymer | 567.0 | 3 | Chemie (IN0) | |||
| 3 | G, H, I (A, B, C) | water | water | 18.0 | 410 | Chemie (HOH) |
Sequence modifications
A, B, C: 31 - 370 (UniProt: P37268)
| PDB | External Database | Details |
|---|---|---|
| Arg 33 | Gln 33 | engineered mutation |
| Asn 34 | Asp 34 | engineered mutation |
| Asn 38 | Ser 38 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 117665.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1701.1 | |
| All* | Total formula weight | 119366.5 |
