PDB: 888 件ウェブページステータス検索Chemie searchBIRD

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7F1Z	Cryo-EM structure of the GDP-bound dopamine receptor 1 and mini-Gs complex without Nb35 分子名称: D(1A) dopamine receptor, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Xiao, T, Zheng, S. 登録日 2021-06-10 公開日 2022-06-15 最終更新日 2022-07-13 実験手法 ELECTRON MICROSCOPY (3.46 Å) 主引用文献 Structural insights into G protein activation by D1 dopamine receptor. Sci Adv, 8, 2022
7F4H	Cryo-EM structure of afamelanotide-bound melanocortin-1 receptor in complex with Gs protein, Nb35 and scFv16 分子名称: Afamelanotide, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E. 登録日 2021-06-18 公開日 2021-09-08 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor. Cell Res., 31, 2021
7F4D	Cryo-EM structure of alpha-MSH-bound melanocortin-1 receptor in complex with Gs protein and Nb35 分子名称: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E. 登録日 2021-06-18 公開日 2021-09-08 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor. Cell Res., 31, 2021
7F4F	Cryo-EM structure of afamelanotide-bound melanocortin-1 receptor in complex with Gs protein and scFv16 分子名称: Afamelanotide, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E. 登録日 2021-06-18 公開日 2021-09-08 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor. Cell Res., 31, 2021
7F4I	Cryo-EM structure of SHU9119-bound melanocortin-1 receptor in complex with Gs protein and Nb35 分子名称: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E. 登録日 2021-06-18 公開日 2021-09-08 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor. Cell Res., 31, 2021
7NA8	Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist 分子名称: 1-(methanesulfonyl)-1'-(2-methyl-L-alanyl-O-benzyl-D-seryl)-1,2-dihydrospiro[indole-3,4'-piperidine], Antibody fragment, CHOLESTEROL, ... 著者 Liu, H, Sun, D, Sun, J, Zhang, C. 登録日 2021-06-20 公開日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren Nat Commun, 12, 2021
7NA7	Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist 分子名称: Antibody fragment, CHOLESTEROL, Ghrelin-27, ... 著者 Liu, H, Sun, D, Sun, J, Zhang, C. 登録日 2021-06-20 公開日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren Nat Commun, 12, 2021
7F58	Cryo-EM structure of THIQ-MC4R-Gs_Nb35 complex 分子名称: (3R)-N-[(2R)-3-(4-chlorophenyl)-1-[4-cyclohexyl-4-(1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-1-oxidanylidene-propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J. 登録日 2021-06-21 公開日 2021-11-03 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res., 31, 2021
7F54	Cryo-EM structure of afamelanotide-MC4R-Gs_Nb35 complex 分子名称: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J. 登録日 2021-06-21 公開日 2021-11-03 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res., 31, 2021
7F55	Cryo-EM structure of bremelanotide-MC4R-Gs_Nb35 complex 分子名称: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J. 登録日 2021-06-21 公開日 2021-11-03 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res., 31, 2021
7F53	Cryo-EM structure of a-MSH-MC4R-Gs_Nb35 complex 分子名称: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J. 登録日 2021-06-21 公開日 2021-11-03 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res., 31, 2021
7F6H	Cryo-EM structure of human bradykinin receptor BK2R in complex Gq proteins and bradykinin 分子名称: Bradykinin, Bradykinin receptor BK2R, CHOLESTEROL, ... 著者 Shen, J, Zhang, D, Fu, Y, Chen, A, Zhang, H. 登録日 2021-06-25 公開日 2022-01-05 最終更新日 2023-01-18 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Cryo-EM structures of human bradykinin receptor-G q proteins complexes. Nat Commun, 13, 2022
7F6I	Cryo-EM structure of human bradykinin receptor BK2R in complex Gq proteins and kallidin 分子名称: Bradykinin receptor BK2R, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Shen, J, Zhang, D, Fu, Y, Chen, A, Zhang, H. 登録日 2021-06-25 公開日 2022-01-05 最終更新日 2023-01-18 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Cryo-EM structures of human bradykinin receptor-G q proteins complexes. Nat Commun, 13, 2022
7F6G	Cryo-EM structure of human angiotensin receptor AT1R in complex Gq proteins and Sar1-AngII 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin receptor AT1R, CHOLESTEROL, ... 著者 Zhang, D, Xu, L, Zhan, Y, Guo, J, Zhang, H. 登録日 2021-06-25 公開日 2023-03-29 最終更新日 2023-10-18 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists. Embo J., 42, 2023
7P00	Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex 分子名称: Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A. 登録日 2021-06-29 公開日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.71 Å) 主引用文献 Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7, 2021
7P02	Human Neurokinin 1 receptor (NK1R) substance P Gs complex 分子名称: Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A. 登録日 2021-06-29 公開日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.87 Å) 主引用文献 Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7, 2021
7RA3	cryo-EM of human Gastric inhibitory polypeptide receptor GIPR bound to GIP 分子名称: Gastric inhibitory polypeptide, Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. 登録日 2021-06-29 公開日 2022-04-13 実験手法 ELECTRON MICROSCOPY (3.24 Å) 主引用文献 Structural determinants of dual incretin receptor agonism by tirzepatide. Proc.Natl.Acad.Sci.USA, 119, 2022
7F8V	Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gi 分子名称: Gastrin-17, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. 登録日 2021-07-02 公開日 2021-10-13 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
7F8W	Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gq 分子名称: Gastrin-17, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. 登録日 2021-07-02 公開日 2021-10-13 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
7RBT	cryo-EM structure of human Gastric inhibitory polypeptide receptor GIPR bound to tirzepatide 分子名称: 2-fluoro-4-[(1R)-6-methoxy-1-methyl-2-{(1S)-1-[4-(propan-2-yl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinolin-5-yl]-6-[(2-methylpropyl)amino]phenol, Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. 登録日 2021-07-06 公開日 2022-04-13 実験手法 ELECTRON MICROSCOPY (3.08 Å) 主引用文献 Structural determinants of dual incretin receptor agonism by tirzepatide. Proc.Natl.Acad.Sci.USA, 119, 2022
7RG9	cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R in apo form 分子名称: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. 登録日 2021-07-14 公開日 2022-04-13 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural determinants of dual incretin receptor agonism by tirzepatide. Proc.Natl.Acad.Sci.USA, 119, 2022
7RGP	cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R bound to tirzepatide 分子名称: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. 登録日 2021-07-15 公開日 2022-04-13 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural determinants of dual incretin receptor agonism by tirzepatide. Proc.Natl.Acad.Sci.USA, 119, 2022
7RKN	Structure of CX3CL1-US28-Gi-scFv16 in OC-state 分子名称: Antibody fragment scFv16, Fractalkine, G-protein coupled receptor homolog US28, ... 著者 Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. 登録日 2021-07-22 公開日 2022-01-26 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
7RKY	Binding mode of US27-Gi-scFv16 in OCL-state 分子名称: Antibody fragment scFv16, G-protein coupled receptor homolog US27, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Tsutsumi, N, Jude, K.M, Garcia, K.C. 登録日 2021-07-22 公開日 2022-01-26 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
7RKX	Structure of US27-Gi-scFv16 in CL-state 分子名称: Antibody fragment scFv16, G-protein coupled receptor homolog US27, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Tsutsumi, N, Jude, K.M, Garcia, K.C. 登録日 2021-07-22 公開日 2022-01-26 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022

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