4JVR
| Co-crystal structure of MDM2 with inhibitor (2'S,3R,4'S,5'R)-N-(2-aminoethyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide | 分子名称: | (2'S,3R,4'S,5'R)-N-(2-aminoethyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, E3 ubiquitin-protein ligase Mdm2 | 著者 | Huang, X, Gonzalez-Lopez de Turiso, F, Sun, D, Yosup, R, Bartberger, M.D, Beck, H.P, Cannon, J, Shaffer, P, Oliner, J.D, Olson, S.H, Medina, J.C. | 登録日 | 2013-03-26 | 公開日 | 2013-05-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors. J.Med.Chem., 56, 2013
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4JVE
| Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid | 分子名称: | (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid, E3 ubiquitin-protein ligase Mdm2 | 著者 | Huang, X, Gonzalez-Lopez de Turiso, F, Sun, D, Yosup, R, Bartberger, M.D, Beck, H.P, Cannon, J, Shaffer, P, Oliner, J.D, Olson, S.H, Medina, J.C. | 登録日 | 2013-03-25 | 公開日 | 2013-05-01 | 最終更新日 | 2013-06-05 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors. J.Med.Chem., 56, 2013
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4S0U
| Crystal structure of NKG2D in complex with ULBP6 | 分子名称: | NKG2-D type II integral membrane protein, Retinoic acid early transcript 1L protein | 著者 | Mohammed, F, Willcox, B.E. | 登録日 | 2015-01-06 | 公開日 | 2016-04-20 | 最終更新日 | 2017-06-14 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding. Sci Signal, 10, 2017
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5MBW
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5MCO
| CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH ACTIVE SITE INHIBITOR GRL-8234 AND EXOSITE PEPTIDE | 分子名称: | BACE-1 EXOSITE PEPTIDE, Beta-secretase 1, N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-[methyl(methylsulfonyl)amino]-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide | 著者 | Kuglstatter, A, Stihle, M, Benz, J. | 登録日 | 2016-11-10 | 公開日 | 2017-09-27 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Potent and Selective BACE-1 Peptide Inhibitors Lower Brain A beta Levels Mediated by Brain Shuttle Transport. EBioMedicine, 24, 2017
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5MCQ
| CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH ACTIVE SITE AND EXOSITE BINDING PEPTIDE INHIBITOR | 分子名称: | 1,2-ETHANEDIOL, BACE-1 ACTIVE AND EXOSITE BINDING INHIBITOR, Beta-secretase 1 | 著者 | Kuglstatter, A, Stihle, M, Benz, J. | 登録日 | 2016-11-10 | 公開日 | 2017-09-27 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Potent and Selective BACE-1 Peptide Inhibitors Lower Brain A beta Levels Mediated by Brain Shuttle Transport. EBioMedicine, 24, 2017
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5KSJ
| Crystal structure of deoxygenated hemoglobin in complex with Sphingosine phosphate | 分子名称: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | 著者 | Ahmed, M.H, Safo, M.K, Xia, Y. | 登録日 | 2016-07-08 | 公開日 | 2017-07-26 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease. Sci Rep, 7, 2017
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5KSI
| Crystal structure of deoxygenated hemoglobin in complex with sphingosine phosphate and 2,3-Bisphosphoglycerate | 分子名称: | (2R)-2,3-diphosphoglyceric acid, (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Hemoglobin subunit alpha, ... | 著者 | Ahmed, M.H, Safo, M.K, Xia, Y. | 登録日 | 2016-07-08 | 公開日 | 2017-07-26 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease. Sci Rep, 7, 2017
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5HJ0
| Crystal Structure of Mis18 'Yippee-like' Domain | 分子名称: | Kinetochore protein mis18, ZINC ION | 著者 | Medina-Pritchard, B, Subramanian, L, Allshire, R, Arockia Jeyaprakash, A. | 登録日 | 2016-01-12 | 公開日 | 2016-03-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Centromere localization and function of Mis18 requires Yippee-like domain-mediated oligomerization. Embo Rep., 17, 2016
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4QMD
| Crystal structure of human envoplakin plakin repeat domain | 分子名称: | Envoplakin | 著者 | Mohammed, F, Al-Jassar, C, White, S.A, Fogl, C, Jeeves, M, Knowles, T.J, Odinstova, E, Rodriguez-Zamora, P, Overduin, M, Chidgey, M. | 登録日 | 2014-06-16 | 公開日 | 2015-07-29 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | 主引用文献 | Mechanism of intermediate filament recognition by plakin repeat domains revealed by envoplakin targeting of vimentin. Nat Commun, 7, 2016
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6AU5
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6AYN
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6AZK
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6AXP
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6AZL
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8TRH
| The IDRc bound human core Mediator complex | 分子名称: | Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ... | 著者 | Chen, S.F, Chao, T.C, Kim, H.J, Tang, H.C, Khadka, S, Li, T, Murakami, K, Boyer, T.G, Tsai, K.L. | 登録日 | 2023-08-09 | 公開日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural basis of the human transcriptional Mediator regulated by its dissociable kinase module. Mol.Cell, 2024
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6W1S
| Atomic model of the mammalian Mediator complex | 分子名称: | Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ... | 著者 | Zhao, H, Young, N, Asturias, F. | 登録日 | 2020-03-04 | 公開日 | 2021-03-10 | 実験手法 | ELECTRON MICROSCOPY (4.02 Å) | 主引用文献 | A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers. Cell, 178, 2019
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4H62
| Structure of the Saccharomyces cerevisiae Mediator subcomplex Med17C/Med11C/Med22C | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mediator of RNA polymerase II transcription subunit 11, Mediator of RNA polymerase II transcription subunit 17, ... | 著者 | Lariviere, L, Plaschka, C, Seizl, M, Wenzeck, L, Kurth, F, Cramer, P. | 登録日 | 2012-09-19 | 公開日 | 2012-10-31 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of the Mediator head module. Nature, 492, 2012
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3V50
| Complex of SHV S130G mutant beta-lactamase complexed to SA2-13 | 分子名称: | (3R)-4-[(4-CARBOXYBUTANOYL)OXY]-N-[(1E)-3-OXOPROP-1-EN-1-YL]-3-SULFINO-D-VALINE, Beta-lactamase, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | 著者 | Wei, K, van den Akker, F. | 登録日 | 2011-12-15 | 公開日 | 2012-08-08 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | The importance of the trans-enamine intermediate as a beta-lactamase inhibition strategy probed in inhibitor-resistant SHV beta-lactamase variants. Chemmedchem, 7, 2012
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3V5M
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4GWQ
| Structure of the Mediator Head Module from S. cerevisiae in complex with the carboxy-terminal domain (CTD) of RNA Polymerase II Rpb1 subunit | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, Mediator of RNA polymerase II transcription subunit 11, Mediator of RNA polymerase II transcription subunit 17, ... | 著者 | Robinson, P.J.J, Bushnell, D.A, Trnka, M.J, Burlingame, A.L, Kornberg, R.D. | 登録日 | 2012-09-03 | 公開日 | 2012-10-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (4.5 Å) | 主引用文献 | Structure of the Mediator Head module bound to the carboxy-terminal domain of RNA polymerase II. Proc.Natl.Acad.Sci.USA, 109, 2012
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2P4H
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2PQ6
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6XP5
| Head-Middle module of Mediator | 分子名称: | HEAT, Med22, Mediator of RNA polymerase II transcription subunit 1, ... | 著者 | Zhang, H.Q, Chen, D.C, Kornberg, R.D. | 登録日 | 2020-07-08 | 公開日 | 2021-03-03 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Mediator structure and conformation change. Mol.Cell, 81, 2021
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2HZM
| Structure of the Mediator head subcomplex Med18/20 | 分子名称: | PHOSPHATE ION, RNA polymerase II mediator complex subunit 18, RNA polymerase II mediator complex subunit 20 | 著者 | Lariviere, L, Geiger, S, Hoeppner, S, Rother, S, Straesser, K, Cramer, P. | 登録日 | 2006-08-09 | 公開日 | 2006-09-12 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20. Nat.Struct.Mol.Biol., 13, 2006
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