4S0U

Crystal structure of NKG2D in complex with ULBP6

Summary for 4S0U

Entry DOI	10.2210/pdb4s0u/pdb
Descriptor	NKG2-D type II integral membrane protein, Retinoic acid early transcript 1L protein (3 entities in total)
Functional Keywords	leukaemia, graft versus leukaemia, c-type lectin domain, immune system, nkg2d, nkg2dl, affinity and autoimmunity
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane ; Single- pass type II membrane protein : P26718 Cell membrane ; Lipid-anchor, GPI-anchor : Q5VY80
Total number of polymer chains	3
Total formula weight	49221.87
Authors	Mohammed, F.,Willcox, B.E. (deposition date: 2015-01-06, release date: 2016-04-20, Last modification date: 2017-06-14)
Primary citation	Zuo, J.,Willcox, C.R.,Mohammed, F.,Davey, M.,Hunter, S.,Khan, K.,Antoun, A.,Katakia, P.,Croudace, J.,Inman, C.,Parry, H.,Briggs, D.,Malladi, R.,Willcox, B.E.,Moss, P. A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding. Sci Signal, 10:-, 2017 Cited by PubMed: 28559451 DOI: 10.1126/scisignal.aai8904 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation