5MCQ

CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH ACTIVE SITE AND EXOSITE BINDING PEPTIDE INHIBITOR

Summary for 5MCQ

• Entry DOI: 10.2210/pdb5mcq/pdb
• Related: 5MBW 5MCO
• Descriptor: Beta-secretase 1, BACE-1 ACTIVE AND EXOSITE BINDING INHIBITOR, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase, exosite
• Biological source: Homo sapiens (Human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P56817
• Total number of polymer chains: 2
• Total formula weight: 48094.91

Authors

Kuglstatter, A.,Stihle, M.,Benz, J. (deposition date: 2016-11-10, release date: 2017-09-27, Last modification date: 2017-11-01)

• Primary citation: Ruderisch, N.,Schlatter, D.,Kuglstatter, A.,Guba, W.,Huber, S.,Cusulin, C.,Benz, J.,Rufer, A.C.,Hoernschemeyer, J.,Schweitzer, C.,Bulau, T.,Gartner, A.,Hoffmann, E.,Niewoehner, J.,Patsch, C.,Baumann, K.,Loetscher, H.,Kitas, E.,Freskgard, P.O.; Potent and Selective BACE-1 Peptide Inhibitors Lower Brain A beta Levels Mediated by Brain Shuttle Transport.; EBioMedicine, 24:76-92, 2017; PubMed: 28923680; DOI: 10.1016/j.ebiom.2017.09.004

Experimental method

X-RAY DIFFRACTION (1.82 Å)