5MCO
CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH ACTIVE SITE INHIBITOR GRL-8234 AND EXOSITE PEPTIDE
Summary for 5MCO
Entry DOI | 10.2210/pdb5mco/pdb |
Related | 5MBW |
Descriptor | Beta-secretase 1, BACE-1 EXOSITE PEPTIDE, N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-[methyl(methylsulfonyl)amino]-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide, ... (4 entities in total) |
Functional Keywords | protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 2 |
Total formula weight | 47622.51 |
Authors | Kuglstatter, A.,Stihle, M.,Benz, J. (deposition date: 2016-11-10, release date: 2017-09-27, Last modification date: 2024-05-01) |
Primary citation | Ruderisch, N.,Schlatter, D.,Kuglstatter, A.,Guba, W.,Huber, S.,Cusulin, C.,Benz, J.,Rufer, A.C.,Hoernschemeyer, J.,Schweitzer, C.,Bulau, T.,Gartner, A.,Hoffmann, E.,Niewoehner, J.,Patsch, C.,Baumann, K.,Loetscher, H.,Kitas, E.,Freskgard, P.O. Potent and Selective BACE-1 Peptide Inhibitors Lower Brain A beta Levels Mediated by Brain Shuttle Transport. EBioMedicine, 24:76-92, 2017 Cited by PubMed: 28923680DOI: 10.1016/j.ebiom.2017.09.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.49 Å) |
Structure validation
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