5KSI

Crystal structure of deoxygenated hemoglobin in complex with sphingosine phosphate and 2,3-Bisphosphoglycerate

Summary for 5KSI

• Entry DOI: 10.2210/pdb5ksi/pdb
• Related: 5KSJ
• Descriptor: Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total)
• Functional Keywords: hemoglobin, sphingosine-1-phosphate, complex, allosteric effector, oxygen transport
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 66976.48

Authors

Ahmed, M.H.,Safo, M.K.,Xia, Y. (deposition date: 2016-07-08, release date: 2017-07-26, Last modification date: 2023-10-04)

• Primary citation: Sun, K.,D'Alessandro, A.,Ahmed, M.H.,Zhang, Y.,Song, A.,Ko, T.P.,Nemkov, T.,Reisz, J.A.,Wu, H.,Adebiyi, M.,Peng, Z.,Gong, J.,Liu, H.,Huang, A.,Wen, Y.E.,Wen, A.Q.,Berka, V.,Bogdanov, M.V.,Abdulmalik, O.,Han, L.,Tsai, A.L.,Idowu, M.,Juneja, H.S.,Kellems, R.E.,Dowhan, W.,Hansen, K.C.,Safo, M.K.,Xia, Y.; Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease.; Sci Rep, 7:15281-15281, 2017; PubMed: 29127281; DOI: 10.1038/s41598-017-13667-8

Experimental method

X-RAY DIFFRACTION (1.8 Å)