5KSI

Crystal structure of deoxygenated hemoglobin in complex with sphingosine phosphate and 2,3-Bisphosphoglycerate

Summary for 5KSI

Related5KSJ
DescriptorHemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total)
Functional Keywordshemoglobin, sphingosine-1-phosphate, complex, allosteric effector, oxygen transport
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total molecular weight66976.48
Authors
Ahmed, M.H.,Safo, M.K.,Xia, Y. (deposition date: 2016-07-08, release date: 2017-07-26, Last modification date: 2017-12-06)
Primary citation
Sun, K.,D'Alessandro, A.,Ahmed, M.H.,Zhang, Y.,Song, A.,Ko, T.P.,Nemkov, T.,Reisz, J.A.,Wu, H.,Adebiyi, M.,Peng, Z.,Gong, J.,Liu, H.,Huang, A.,Wen, Y.E.,Wen, A.Q.,Berka, V.,Bogdanov, M.V.,Abdulmalik, O.,Han, L.,Tsai, A.L.,Idowu, M.,Juneja, H.S.,Kellems, R.E.,Dowhan, W.,Hansen, K.C.,Safo, M.K.,Xia, Y.
Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease.
Sci Rep, 7:15281-15281, 2017
PubMed: 29127281 (PDB entries with the same primary citation)
DOI: 10.1038/s41598-017-13667-8
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.217700.6%2.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5ksi
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Molmil generated image of 5ksi
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Molmil generated image of 5ksi
rotated about y axis by 90°