PDB: 347 件ウェブページステータス検索Chemie searchBIRD

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3WF7	Crystal structure of S6K1 kinase domain in complex with a purine derivative 1-(9H-purin-6-yl)-N-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide 分子名称: 1-(9H-purin-6-yl)-N-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide, GLYCEROL, Ribosomal protein S6 kinase beta-1, ... 著者 Niwa, H, Shirouzu, M, Yokoyama, S. 登録日 2013-07-17 公開日 2014-08-06 最終更新日 2014-10-29 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal structures of the S6K1 kinase domain in complexes with inhibitors J.Struct.Funct.Genom., 15, 2014
3WF5	Crystal structure of S6K1 kinase domain in complex with a pyrazolopyrimidine derivative 4-[4-(1H-benzimidazol-2-yl)piperidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine 分子名称: 4-[4-(1H-benzimidazol-2-yl)piperidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine, Ribosomal protein S6 kinase beta-1, ZINC ION 著者 Niwa, H, Shirouzu, M, Yokoyama, S. 登録日 2013-07-17 公開日 2014-08-06 最終更新日 2014-10-29 実験手法 X-RAY DIFFRACTION (2.099 Å) 主引用文献 Crystal structures of the S6K1 kinase domain in complexes with inhibitors J.Struct.Funct.Genom., 15, 2014
3WF8	Crystal structure of S6K1 kinase domain in complex with a quinoline derivative 2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl 7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline-11-carboxylate 分子名称: 2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl 7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline-11-carboxylate, GLYCEROL, Ribosomal protein S6 kinase beta-1, ... 著者 Niwa, H, Shirouzu, M, Yokoyama, S. 登録日 2013-07-17 公開日 2014-08-06 最終更新日 2014-10-29 実験手法 X-RAY DIFFRACTION (1.975 Å) 主引用文献 Crystal structures of the S6K1 kinase domain in complexes with inhibitors J.Struct.Funct.Genom., 15, 2014
8DKE	Cryo-EM structure of cystinosin in a cytosol-open state 分子名称: Fab 3H5 Heavy chain, Fab 3H5 Kappa chain, Isoform 2 of Cystinosin 著者 Schmiege, P, Li, X. 登録日 2022-07-05 公開日 2022-09-21 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3.18 Å) 主引用文献 Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022
8DKW	Cryo-EM structure of cystinosin N288K mutant in a cytosol-open state at pH5.0 分子名称: Fab 3H5 Heavy Chain, Fab 3H5 Kappa Chain, Isoform 2 of Cystinosin 著者 Schmiege, P, Li, X. 登録日 2022-07-06 公開日 2022-09-21 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3.09 Å) 主引用文献 Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022
8DKI	Cryo-EM structure of cystinosin in a lumen-open state 分子名称: Fab 3H5 Heavy Chain, Fab 3H5 Kappa chain, Isoform 2 of Cystinosin 著者 Schmiege, P, Li, X. 登録日 2022-07-05 公開日 2022-09-21 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3.32 Å) 主引用文献 Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022
8DKX	Cryo-EM structure of cystinosin N288K mutant in a cytosol-open state at pH7.5 分子名称: Fab 3H5 Heavy Chain, Fab 3H5 Kappa Chain, Isoform 2 of Cystinosin 著者 Schmiege, P, Li, X. 登録日 2022-07-06 公開日 2022-09-21 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022
8DKM	Cryo-EM structure of cystine-bound cystinosin in a lumen-open state 分子名称: Fab 3H5 Heavy Chain, Fab 3H5 Kappa chain, Isoform 2 of Cystinosin, ... 著者 Schmiege, P, Li, X. 登録日 2022-07-05 公開日 2022-09-21 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3.39 Å) 主引用文献 Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022
8DYP	Crystal structure of human cystine transporter cystinosin 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Cystinosin, Nanobody P10, ... 著者 Guo, X, Feng, L. 登録日 2022-08-04 公開日 2022-11-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022
8FNY	Nucleotide-bound structure of a functional construct of eukaryotic elongation factor 2 kinase. 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... 著者 Piserchio, A, Isiorho, E.A, Dalby, K.N, Ghose, R. 登録日 2022-12-28 公開日 2023-05-03 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin. Proc.Natl.Acad.Sci.USA, 120, 2023
8FO6	Nucleotide-free structure of a functional construct of eukaryotic elongation factor 2 kinase. 分子名称: CALCIUM ION, Calmodulin-1, Eukaryotic elongation factor 2 kinase, ... 著者 Piserchio, A, Isiorho, E.A, Dalby, K.N, Ghose, R. 登録日 2022-12-29 公開日 2023-05-03 実験手法 X-RAY DIFFRACTION (2.553 Å) 主引用文献 ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin. Proc.Natl.Acad.Sci.USA, 120, 2023
4EKL	Akt1 with GDC0068 分子名称: (2S)-2-(4-chlorophenyl)-1-{4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl}-3-(propan-2-ylamino)propan-1-one, RAC-alpha serine/threonine-protein kinase 著者 Wu, W.-I, Vigers, G.P.A, Morales, T.H, Brandhuber, B.J. 登録日 2012-04-09 公開日 2012-05-23 最終更新日 2018-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt. Sci.Signal., 5, 2012
4EKK	Akt1 with AMP-PNP 分子名称: Glycogen synthase kinase-3 beta, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Wu, W.-I, Vigers, G.P.A, Morales, T.H, Brandhuber, B.J. 登録日 2012-04-09 公開日 2012-05-23 最終更新日 2018-01-24 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt. Sci.Signal., 5, 2012
4GV1	PKB alpha in complex with AZD5363 分子名称: 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide, GLYCEROL, RAC-alpha serine/threonine-protein kinase 著者 Addie, M, Ballard, P, Bird, G, Buttar, D, Currie, G, Davies, B, Debreczeni, J, Dry, H, Dudley, P, Greenwood, R, Hatter, G, Jestel, A, Johnson, P.D, Kettle, J.G, Lane, C, Lamont, G, Leach, A, Luke, R.W.A, Ogilvie, D, Page, K, Pass, M, Steinbacher, S, Steuber, H, Pearson, S, Ruston, L. 登録日 2012-08-30 公開日 2013-02-27 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases. J.Med.Chem., 56, 2013
4FUL	PI3 Kinase Gamma bound to a pyrmidine inhibitor 分子名称: 4-({4-[3-(piperidin-1-ylcarbonyl)phenyl]pyrimidin-2-yl}amino)benzenesulfonamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 著者 Gopalsamy, A, Bennett, E.M, Shi, M, Zhang, W.G, Bard, J, Yu, K. 登録日 2012-06-28 公開日 2012-10-17 最終更新日 2012-10-31 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
8JOW	Crystal structure of rabbit antibody with phosphorylated peptide bound 分子名称: ARG-PRO-HIS-PHE-PRO-GLN-PHE-SEP-TYR-SER-ALA-SER, Antibody (scFv), CHLORIDE ION 著者 Caaveiro, J.M.M, Kawade, R, Tsumoto, K. 登録日 2023-06-08 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Origin of high binding affinity and selectivity of phosphorylated epitope-specific rabbit antibodies To Be Published
4KK1	Crystal Structure of TSC1 core domain from S. pombe 分子名称: Tuberous sclerosis 1 protein homolog 著者 Sun, W, Zhu, Y, Wang, Z.Z, Zhong, Q, Gao, F, Lou, J.Z, Gong, W.M, Xu, W.Q. 登録日 2013-05-05 公開日 2013-07-17 最終更新日 2013-07-31 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations. Nat Commun, 4, 2013
4KK0	Crystal Structure of TSC1 core domain from S. pombe 分子名称: Tuberous sclerosis 1 protein homolog 著者 Sun, W, Zhu, Y, Wang, Z.Z, Zhong, Q, Gao, F, Lou, J.Z, Gong, W.M, Xu, W.Q. 登録日 2013-05-05 公開日 2013-07-17 最終更新日 2013-07-31 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations. Nat Commun, 4, 2013
3MVH	Crystal structure of Akt-1-inhibitor complexes 分子名称: GSK3-beta peptide, MANGANESE (II) ION, N-{[(3S)-3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl]methyl}-2,4-difluorobenzamide, ... 著者 Pandit, J. 登録日 2010-05-04 公開日 2010-06-02 最終更新日 2021-10-06 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Design of selective, ATP-competitive inhibitors of Akt. J.Med.Chem., 53, 2010
3MV5	Crystal structure of Akt-1-inhibitor complexes 分子名称: (3R)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine, GSK3-beta peptide, MANGANESE (II) ION, ... 著者 Pandit, J. 登録日 2010-05-03 公開日 2010-06-02 最終更新日 2021-10-06 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Design of selective, ATP-competitive inhibitors of Akt. J.Med.Chem., 53, 2010
3M93	Complex crystal structure of Ascaris suum eIF4E-3 with m7G cap 分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, Translation initiation factor 4E 著者 Liu, W, Berkeley Structural Genomics Center (BSGC) 登録日 2010-03-19 公開日 2011-07-20 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis for nematode eIF4E binding an m2,2,7G-Cap and its implications for translation initiation. Nucleic Acids Res., 39, 2011
3M94	Complex crystal structure of Ascaris suum eIF4E-3 with m2,2,7G cap 分子名称: ACETYL GROUP, Eukaryotic translation initiation factor 4E-binding protein 1, N,N,7-trimethylguanosine 5'-(trihydrogen diphosphate), ... 著者 Liu, W, Berkeley Structural Genomics Center (BSGC) 登録日 2010-03-19 公開日 2011-07-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural basis for nematode eIF4E binding an m2,2,7G-Cap and its implications for translation initiation. Nucleic Acids Res., 39, 2011
5WKP	Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and Iron-Sulfur Cluster Scaffold Protein ISCU1, and E. coli ACP1 protein at 3.15A 分子名称: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ... 著者 Boniecki, M.T, Cygler, M. 登録日 2017-07-25 公開日 2017-11-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex. Nat Commun, 8, 2017
5WLW	Crystal Structure of the Human Mitochondrial Cysteine Desulfurase with active Cysteine Loop within ISCU1 active site, coordinating Zn ion. Complexed with human ISD11 and E. coli ACP1 at 3.3A. 分子名称: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ... 著者 Boniecki, M.T, Cygler, M. 登録日 2017-07-27 公開日 2017-11-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.317 Å) 主引用文献 Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex. Nat Commun, 8, 2017
7SOO	LaM domain of human LARP1 分子名称: Isoform 2 of La-related protein 1, SODIUM ION, SULFATE ION 著者 Kozlov, G, Gehring, K. 登録日 2021-11-01 公開日 2022-08-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural basis of 3'-end poly(A) RNA recognition by LARP1. Nucleic Acids Res., 50, 2022

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