PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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4Y4P	Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to mRNA and A-, P- and E-site tRNAs at 2.5A resolution 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... 著者 Polikanov, Y.S, Melnikov, S.V, Soll, D, Steitz, T.A. 登録日 2015-02-10 公開日 2015-03-18 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly. Nat.Struct.Mol.Biol., 22, 2015
8DTM	Cryo-EM structure of insulin receptor (IR) bound with S597 component 2 分子名称: Insulin mimetic peptide S597 component 2, Insulin receptor 著者 Park, J, Li, J, Mayer, J.P, Ball, K.A, Wu, J.Y, Hall, C, Accili, D, Stowell, M.H.B, Bai, X.C, Choi, E. 登録日 2022-07-26 公開日 2022-09-07 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Activation of the insulin receptor by an insulin mimetic peptide. Nat Commun, 13, 2022
2BNI	pLI mutant E20C L16G Y17H, antiparallel 分子名称: GENERAL CONTROL PROTEIN GCN4 著者 Yadav, M.K, Leman, L.J, Stout, C.D, Ghadiri, M.R. 登録日 2005-03-24 公開日 2005-03-30 最終更新日 2019-05-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure-Based Engineering of Internal Cavities in Coiled-Coil Peptides Biochemistry, 44, 2005
6SJA	Structure of HPV16 E6 oncoprotein in complex with IRF3 LxxLL motif 分子名称: Maltose/maltodextrin-binding periplasmic protein,Interferon regulatory factor 3, Protein E6, ZINC ION, ... 著者 Suarez, I.P, Cousido-Siah, A, Bonhoure, A, Mitschler, A, Podjarny, A, Trave, G. 登録日 2019-08-13 公開日 2019-09-04 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Deciphering de molecular and structural interaction between IRF3 and HPV16 E6 To be published
5FTL	Cryo-EM structure of human p97 bound to ATPgS (Conformation I) 分子名称: ADENOSINE-5'-DIPHOSPHATE, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE 著者 Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. 登録日 2016-01-14 公開日 2016-01-27 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition Science, 351, 2016
4YTT	Crystal structure of D-tagatose 3-epimerase C66S from Pseudomonas cichorii in complex with 6-deoxy L-psicose 分子名称: 6-deoxy-L-psicose, 6-deoxy-alpha-L-psicofuranose, D-tagatose 3-epimerase, ... 著者 Yoshida, H, Yoshihara, A, Ishii, T, Izumori, K, Kamitori, S. 登録日 2015-03-18 公開日 2016-03-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 X-ray structures of the Pseudomonas cichorii D-tagatose 3-epimerase mutant form C66S recognizing deoxy sugars as substrates Appl. Microbiol. Biotechnol., 100, 2016
5FTN	Cryo-EM structure of human p97 bound to ATPgS (Conformation III) 分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE 著者 Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. 登録日 2016-01-14 公開日 2016-01-27 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition Science, 351, 2016
6XQE	Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UAA-mRNA, and deacylated P-site tRNA at 3.00A resolution 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... 著者 Batool, Z, Lomakin, I.B, Bunick, C.G, Polikanov, Y.S. 登録日 2020-07-09 公開日 2020-08-05 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Proc.Natl.Acad.Sci.USA, 117, 2020
4YWV	Structural insight into the substrate inhibition mechanism of NADP+-dependent succinic semialdehyde dehydrogenase from Streptococcus pyogenes 分子名称: 4-oxobutanoic acid, SULFATE ION, Succinic semialdehyde dehydrogenase 著者 Park, S.A, Jang, E.H, Chi, Y.M, Lee, K.S. 登録日 2015-03-21 公開日 2015-05-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural insight into the substrate inhibition mechanism of NADP(+)-dependent succinic semialdehyde dehydrogenase from Streptococcus pyogenes. Biochem.Biophys.Res.Commun., 461, 2015
6FTI	Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Programmed 80S Ribosome 分子名称: 28S rRNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... 著者 Braunger, K, Becker, T, Beckmann, R. 登録日 2018-02-22 公開日 2018-03-21 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum. Science, 360, 2018
6Q6G	Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D1 box class 分子名称: Anaphase-promoting complex subunit 1,Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... 著者 Zhang, S, Barford, D. 登録日 2018-12-11 公開日 2019-09-11 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C. Nat Commun, 10, 2019
4YTV	Crystal structure of Mdm35 分子名称: COBALT (II) ION, GLYCEROL, Mitochondrial distribution and morphology protein 35 著者 Watanabe, Y, Tamura, Y, Kawano, S, Endo, T. 登録日 2015-03-18 公開日 2015-08-12 最終更新日 2020-02-05 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structural and mechanistic insights into phospholipid transfer by Ups1-Mdm35 in mitochondria. Nat Commun, 6, 2015
6XHX	Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with erythromycin and protein Y (YfiA) at 2.55A resolution 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... 著者 Svetlov, M.S, Syroegin, E.A, Aleksandrova, E.V, Atkinson, G.C, Gregory, S.T, Mankin, A.S, Polikanov, Y.S. 登録日 2020-06-19 公開日 2020-12-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance. Nat.Chem.Biol., 17, 2021
4YTW	Crystal structure of Ups1-Mdm35 complex 分子名称: Mitochondrial distribution and morphology protein 35, Protein UPS1, mitochondrial 著者 Watanabe, Y, Tamura, Y, Kawano, S, Endo, T. 登録日 2015-03-18 公開日 2015-08-12 最終更新日 2020-02-05 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structural and mechanistic insights into phospholipid transfer by Ups1-Mdm35 in mitochondria. Nat Commun, 6, 2015
1Q0A	Crystal structure of the Zn(II) form of E. coli ZntR, a zinc-sensing transcriptional regulator (space group C222) 分子名称: SULFATE ION, ZINC ION, Zn(II)-responsive regulator of zntA 著者 Changela, A, Chen, K, Xue, Y, Holschen, J, Outten, C.E, O'Halloran, T.V, Mondragon, A. 登録日 2003-07-15 公開日 2003-09-16 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR Science, 301, 2003
4YTX	Crystal structure of Ups1-Mdm35 complex with PA 分子名称: 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, Mitochondrial distribution and morphology protein 35, Protein UPS1, ... 著者 Watanabe, Y, Tamura, Y, Kawano, S, Endo, T. 登録日 2015-03-18 公開日 2015-08-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural and mechanistic insights into phospholipid transfer by Ups1-Mdm35 in mitochondria. Nat Commun, 6, 2015
4YPB	Precleavage 70S structure of the P. vulgaris HigB DeltaH92 toxin bound to the AAA codon 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Schureck, M.A, Dunkle, J.A, Maehigashi, T, Dunham, C.M. 登録日 2015-03-12 公開日 2015-10-21 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Defining the mRNA recognition signature of a bacterial toxin protein. Proc.Natl.Acad.Sci.USA, 112, 2015
6XWS	Crystal Structure of Drosophila CAL1 1-160 bound to CENP-A/H4 分子名称: Chromosome alignment defect 1,Chromosome alignment defect 1, Histone H3-like centromeric protein cid, Histone H4 著者 Jeyaprakash, A.A, Medina-Pritchard, B, Lazou, V, Zou, J, Byron, O, Abad, M.A, Rappsilber, J, Heun, P. 登録日 2020-01-24 公開日 2020-04-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (4.36 Å) 主引用文献 Structural basis for centromere maintenance by Drosophila CENP-A chaperone CAL1. Embo J., 39, 2020
6UHY	WDR5 in complex with Myc site fragment inhibitor 分子名称: 1-cyclohexyl-1H-benzimidazole-5-carboxylic acid, WDR5 著者 Wang, F, Fesik, S.W. 登録日 2019-09-29 公開日 2020-04-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6UHZ	WDR5 in complex with Myc site fragment inhibitor 分子名称: 1-cyclohexyl-1H-benzotriazole-5-carboxylic acid, WDR5 著者 Wang, F, Fesik, S.w. 登録日 2019-09-29 公開日 2020-04-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.258 Å) 主引用文献 Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
8IH8	anti-sigmaF factor and Anti-sigmaF factor antagonist complex(usfx-RsfB) 分子名称: Anti-sigma-F factor RsbW, Anti-sigma-F factor antagonist RsfB, GLYCEROL 著者 Chen, Y.J, Su, D. 登録日 2023-02-22 公開日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 High resolutions crystal structure of anti-sigmaF factor and Anti-sigmaF factor antagonist complex(usfx-RsfB) To Be Published
8EV2	Dual Modulators 分子名称: (3aS,4R,9bR)-4-(2-chloro-4-hydroxyphenyl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[c]quinoline-8-sulfonamide, (3~{a}~{R},4~{S},9~{b}~{S})-4-(2-chloranyl-4-oxidanyl-phenyl)-2,3,3~{a},4,5,9~{b}-hexahydro-1~{H}-cyclopenta[c]quinoline-8-sulfonamide, Estrogen receptor, ... 著者 Tinivella, A, Nwachukwu, J.C, Angeli, A, Foschi, F, Benatti, A.L, Pinzi, L, Izard, T, Ferraroni, M, Rangarajan, E.S, Christodoulou, M, Passarella, D, Supuran, C, Nettles, K.W, Rastelli, G. 登録日 2022-10-19 公開日 2022-12-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors. Eur.J.Med.Chem., 246, 2022
7AZO	70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977 分子名称: (2R,3S,4R,5R,7S,9S,10S,11R,12S,13R)-12-(((2R,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-2-((S)-1-(((2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)propan-2-yl)-10-(((2S,3R,4R,6R)-3-hydroxy-4-(methoxyamino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,5,7,9,11,13-hexamethyl-7-(((2-((2-nitrophenyl)sulfonamido)ethyl)carbamoyl)oxy)-6,14-dioxooxacyclotetradecan-4-yl 3-methylbutanoate, 16S rRNA, 23S rRNA, ... 著者 Jenner, L.B, Yusupov, M, Yusupova, G. 登録日 2020-11-17 公開日 2022-06-01 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents. Cell, 186, 2023
7RQD	Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MTI-tripeptidyl-tRNA analog ACCA-ITM, and chloramphenicol at 2.50A resolution 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... 著者 Syroegin, E.A, Flemmich, L, Klepacki, D, Vazquez-Laslop, N, Micura, R, Polikanov, Y.S. 登録日 2021-08-06 公開日 2022-01-26 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol. Nat.Struct.Mol.Biol., 29, 2022
7RQE	Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MAI-tripeptidyl-tRNA analog ACCA-IAM, and chloramphenicol at 2.40A resolution 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... 著者 Syroegin, E.A, Flemmich, L, Klepacki, D, Vazquez-Laslop, N, Micura, R, Polikanov, Y.S. 登録日 2021-08-06 公開日 2022-01-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol. Nat.Struct.Mol.Biol., 29, 2022

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