6XQE

Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UAA-mRNA, and deacylated P-site tRNA at 3.00A resolution

This is a non-PDB format compatible entry.

Summary for 6XQE

• Entry DOI: 10.2210/pdb6xqe/pdb
• Descriptor: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (60 entities in total)
• Functional Keywords: sarecycline; tetracycline; antibiotic; 70s ribosome; x-ray structure; inhibition of translation; decoding center; acne vulgaris, ribosome
• Biological source: Escherichia coli; More
• Total number of polymer chains: 108
• Total formula weight: 4469044.26

Authors

Batool, Z.,Lomakin, I.B.,Bunick, C.G.,Polikanov, Y.S. (deposition date: 2020-07-09, release date: 2020-08-05, Last modification date: 2023-11-15)

• Primary citation: Batool, Z.,Lomakin, I.B.,Polikanov, Y.S.,Bunick, C.G.; Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome.; Proc.Natl.Acad.Sci.USA, 117:20530-20537, 2020; PubMed: 32817463; DOI: 10.1073/pnas.2008671117

Experimental method

X-RAY DIFFRACTION (3 Å)