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6UHY

WDR5 in complex with Myc site fragment inhibitor

Summary for 6UHY
Entry DOI10.2210/pdb6uhy/pdb
DescriptorWDR5, 1-cyclohexyl-1H-benzimidazole-5-carboxylic acid (3 entities in total)
Functional Keywordswdr5, myc, inhibitor, complex, transcription
Biological sourceHomo sapiens
Total number of polymer chains2
Total formula weight67472.62
Authors
Wang, F.,Fesik, S.W. (deposition date: 2019-09-29, release date: 2020-04-15, Last modification date: 2024-03-13)
Primary citationChacon Simon, S.,Wang, F.,Thomas, L.R.,Phan, J.,Zhao, B.,Olejniczak, E.T.,Macdonald, J.D.,Shaw, J.G.,Schlund, C.,Payne, W.,Creighton, J.,Stauffer, S.R.,Waterson, A.G.,Tansey, W.P.,Fesik, S.W.
Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design.
J.Med.Chem., 63:4315-4333, 2020
Cited by
PubMed: 32223236
DOI: 10.1021/acs.jmedchem.0c00224
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.26 Å)
Structure validation

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