PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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3B6O	Structure of TREX1 in complex with a nucleotide and an inhibitor ion (lithium) 分子名称: LITHIUM ION, THYMIDINE-5'-PHOSPHATE, Three prime repair exonuclease 1 著者 Brucet, M, Querol-Audi, J, Fita, I, Celada, A. 登録日 2007-10-29 公開日 2008-09-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases. Protein Sci., 17, 2008
4CJT	Interrogating HIV integrase for compounds that bind- a SAMPL challenge 分子名称: 1,2-benzoxazol-3-amine, ACETATE ION, GLYCEROL, ... 著者 Peat, T.S. 登録日 2013-12-23 公開日 2014-01-08 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Interrogating HIV Integrase for Compounds that Bind- a Sampl Challenge. J.Comput.Aided Mol.Des., 28, 2014
6CXS	Crystal Structure of Clostridium perfringens beta-glucuronidase bound with a novel, potent inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine 分子名称: 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine, Beta-glucuronidase, Maltose/maltodextrin-binding periplasmic protein 著者 Wallace, B.D, Redinbo, M.R. 登録日 2018-04-04 公開日 2019-04-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Targeted inhibition of gut bacterial beta-glucuronidase activity enhances anticancer drug efficacy. Proc.Natl.Acad.Sci.USA, 2020
6CYO	Crystal structure of human UBE2A (RAD6A) 分子名称: Ubiquitin-conjugating enzyme E2 A 著者 Ranzani, A.T, de Oliveira, J.F. 登録日 2018-04-06 公開日 2018-12-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Mechanistic insights revealed by a UBE2A mutation linked to intellectual disability. Nat. Chem. Biol., 15, 2019
6D65	Crystal structure of the human dual specificity phosphatase 1 catalytic domain (C258S) as a maltose binding protein fusion in complex with the designed AR protein off7 分子名称: Designed AR protein off7, ETHANOL, GLYCEROL, ... 著者 Gumpena, R, Lountos, G.T, Waugh, D.S. 登録日 2018-04-20 公開日 2018-09-19 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.348 Å) 主引用文献 MBP-binding DARPins facilitate the crystallization of an MBP fusion protein. Acta Crystallogr F Struct Biol Commun, 74, 2018
6ND0	human BK channel reconstituted into liposomes 分子名称: Calcium-activated potassium channel subunit alpha-1 著者 Wang, L, Tonggu, L. 登録日 2018-12-13 公開日 2020-06-17 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Broken symmetry in the human BK channel To Be Published
3B6P	Structure of TREX1 in complex with a nucleotide and inhibitor ions (sodium and zinc) 分子名称: SODIUM ION, THYMIDINE-5'-PHOSPHATE, Three prime repair exonuclease 1, ... 著者 Brucet, M, Querol-Audi, J, Fita, I, Celada, A. 登録日 2007-10-29 公開日 2008-09-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases. Protein Sci., 17, 2008
6NF9	Structure of M. spretus Endogenous Virus Element (EVE) Virus-like particle (VLP) 分子名称: Mus Spretus Endogenous Viral Element 著者 Callaway, H.M, Subramanian, S. 登録日 2018-12-19 公開日 2019-01-23 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.89 Å) 主引用文献 Examination and Reconstruction of Three Ancient Endogenous Parvovirus Capsid Protein Gene Remnants Found in Rodent Genomes. J. Virol., 93, 2019
6DC6	Crystal structure of human ubiquitin activating enzyme E1 (Uba1) in complex with ubiquitin 分子名称: MAGNESIUM ION, PYROPHOSPHATE 2-, Ubiquitin, ... 著者 Lv, Z, Yuan, L, Williams, K.M, Atkison, J.H, Olsen, S.K. 登録日 2018-05-04 公開日 2018-10-10 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.14 Å) 主引用文献 Crystal structure of a human ubiquitin E1-ubiquitin complex reveals conserved functional elements essential for activity. J. Biol. Chem., 293, 2018
8F93	WDR5 covalently modified at Y228 by (R)-2-SF 分子名称: 3-ethynyl-5-{[(3R)-4-{1-[(2-methoxyphenyl)methyl]-1H-benzimidazole-5-carbonyl}-3-methylpiperazin-1-yl]methyl}benzene-1-sulfonyl fluoride, CHLORIDE ION, GLYCEROL, ... 著者 Taunton, J, Craven, G.B, Chen, Y. 登録日 2022-11-23 公開日 2023-05-31 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes. Nat.Chem., 15, 2023
1I1N	HUMAN PROTEIN L-ISOASPARTATE O-METHYLTRANSFERASE WITH S-ADENOSYL HOMOCYSTEINE 分子名称: PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE, S-ADENOSYL-L-HOMOCYSTEINE 著者 Smith, C.D, Chattopadhyay, D, Carson, M, Friedman, A.M, Skinner, M.M. 登録日 2001-02-02 公開日 2002-03-13 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal structure of human L-isoaspartyl-O-methyl-transferase with S-adenosyl homocysteine at 1.6-A resolution and modeling of an isoaspartyl-containing peptide at the active site. Protein Sci., 11, 2002
1I6U	RNA-PROTEIN INTERACTIONS: THE CRYSTAL STRUCTURE OF RIBOSOMAL PROTEIN S8/RRNA COMPLEX FROM METHANOCOCCUS JANNASCHII 分子名称: 16S RRNA FRAGMENT, 30S RIBOSOMAL PROTEIN S8P, SULFATE ION 著者 Tishchenko, S, Nikulin, A, Fomenkova, N, Nevskaya, N, Nikonov, O, Dumas, P, Moine, H, Ehresmann, B, Ehresmann, C, Piendl, W, Lamzin, V, Garber, M, Nikonov, S. 登録日 2001-03-05 公開日 2001-08-03 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Detailed analysis of RNA-protein interactions within the ribosomal protein S8-rRNA complex from the archaeon Methanococcus jannaschii. J.Mol.Biol., 311, 2001
6NKL	2.2 A resolution structure of VapBC-1 from nontypeable Haemophilus influenzae 分子名称: Antitoxin VapB1, Ribonuclease VapC 著者 Lovell, S, Kashipathy, M.M, Battaile, K.P, Molinaro, A.L, Daines, D.A. 登録日 2019-01-07 公開日 2019-04-10 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal Structure of VapBC-1 from Nontypeable Haemophilus influenzae and the Effect of PIN Domain Mutations on Survival during Infection. J.Bacteriol., 201, 2019
6NT7	Cryo-EM structure of full-length chicken STING in the cGAMP-bound dimeric state 分子名称: Stimulator of interferon genes protein, cGAMP 著者 Shang, G, Zhang, C, Chen, Z.J, Bai, X, Zhang, X. 登録日 2019-01-28 公開日 2019-03-06 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP. Nature, 567, 2019
6NUI	Human Guanylate Kinase 分子名称: Guanylate kinase 著者 Sabo, T.M, Khan, N, Ban, D, Trigo-Mourino, P, Carneiro, M.G, Trent, J.O, Konrad, M, Lee, D. 登録日 2019-02-01 公開日 2019-06-26 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer. J.Biol.Chem., 294, 2019
6NHJ	Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development 分子名称: Major capsid protein, Minor capsid protein, Small capsomere-interacting protein, ... 著者 Liu, W, Dai, X.H, Jih, J, Chan, K, Trang, P, Yu, X.K, Balogun, R, Mei, Y, Liu, F.Y, Zhou, Z.H. 登録日 2018-12-22 公開日 2019-03-06 最終更新日 2019-11-27 実験手法 ELECTRON MICROSCOPY (5 Å) 主引用文献 Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development. PLoS Pathog., 15, 2019
6DBY	Crystal structure of Nudix 1 from Arabidopsis thaliana 分子名称: MAGNESIUM ION, Nudix hydrolase 1 著者 Noel, J.P, Thomas, S.T, Dudareva, N, Henry, L.K. 登録日 2018-05-03 公開日 2018-09-19 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Contribution of isopentenyl phosphate to plant terpenoid metabolism. Nat Plants, 4, 2018
6NML	Ternary structure of the T130K mutant of ANT-4'' with Neomycin and AMPCPP 分子名称: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, Kanamycin nucleotidyltransferase, MAGNESIUM ION, ... 著者 Cuneo, M.J, Selvaraj, B. 登録日 2019-01-11 公開日 2020-01-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 'Catch and Release": a Variation of the Archetypal Nucleotidyl Transfer Reaction Acs Catalysis, 2020
3L0L	Crystal structure of orphan nuclear receptor RORgamma in complex with natural ligand 分子名称: 25-HYDROXYCHOLESTEROL, Nuclear receptor ROR-gamma, SCR2-2 著者 Martynowski, D, Li, Y. 登録日 2009-12-10 公開日 2010-03-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. Mol.Endocrinol., 24, 2010
4CIO	RRM domain from C. elegans SUP-12 bound to GGUGUGC RNA 分子名称: 5'-R(*GP*GP*UP*GP*UP*GP*CP)-3', PROTEIN SUP-12, ISOFORM A 著者 Amrane, S, Mackereth, C.D. 登録日 2013-12-12 公開日 2014-09-03 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Backbone-Independent Nucleic Acid Binding by Splicing Factor Sup-12 Reveals Key Aspects of Molecular Recognition Nat.Commun., 5, 2014
4DAT	Structure of 14-3-3 sigma in complex with PADI6 14-3-3 binding motif II 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, Peptidylarginine Deiminase type VI 著者 Rose, R, Rose, M, Ottmann, C. 登録日 2012-01-13 公開日 2012-06-13 最終更新日 2012-10-24 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI. J.Struct.Biol., 180, 2012
3OLF	Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-methylbenzoic acid 分子名称: 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-methylbenzoic acid, Bile acid receptor, peptide of Nuclear receptor coactivator 1 著者 Rudolph, M.G. 登録日 2010-08-26 公開日 2011-01-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties Bioorg.Med.Chem.Lett., 21, 2011
6DM8	Understanding the Species Selectivity of Myeloid cell leukemia-1 (Mcl-1) inhibitors 分子名称: 4-{8-chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-[1,4]diazepino[1,2-a]indol-2(3H)-yl}-1-methyl-1H-indole-6-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog - MBP chimera, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose 著者 Zhao, B. 登録日 2018-06-04 公開日 2018-08-01 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Understanding the Species Selectivity of Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors. Biochemistry, 57, 2018
4DBR	Myosin VI D179Y (MD) pre-powerstroke state 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Pylypenko, O, Sweeney, H.L, Houdusse, A. 登録日 2012-01-16 公開日 2013-01-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Mutations in myosin VI that cause a loss of coordination between heads provide insights into the structural changes underlying force generation and the importance of gating To be Published
6O2D	Schizosaccharomyces pombe Cnp3 Cupin Domain 分子名称: Inner kinetochore subunit cnp3 著者 Chik, J.K, Cho, U.S. 登録日 2019-02-22 公開日 2019-08-21 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Structures of CENP-C cupin domains at regional centromeres reveal unique patterns of dimerization and recruitment functions for the inner pocket. J.Biol.Chem., 294, 2019

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