PDB: 243083 件ウェブページステータス検索Chemie searchBIRD

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7SGZ	Structure of the yeast Rad24-RFC loader bound to DNA and the closed 9-1-1 clamp 分子名称: ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, Crick strand, ... 著者 Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. 登録日 2021-10-07 公開日 2022-03-23 最終更新日 2025-05-14 実験手法 ELECTRON MICROSCOPY (3.17 Å) 主引用文献 DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp. Nat.Struct.Mol.Biol., 29, 2022
9J0P	Arrested elongation complex of mammalian RNA polymerase II with nucleosome (AEC2-nuc) 分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB11-a, ... 著者 Naganuma, M, Kujirai, T, Ehara, H, Uejima, T, Ito, T, Goto, M, Aoki, M, Henmi, M, Miyamoto-Kohno, S, Shirouzu, M, Kurumizaka, H, Sekine, S. 登録日 2024-08-02 公開日 2025-02-05 最終更新日 2025-07-02 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural insights into promoter-proximal pausing of RNA polymerase II at +1 nucleosome. Sci Adv, 11, 2025
6SMN	A. thaliana serine hydroxymethyltransferase isoform 2 (AtSHMT2) in complex with methotrexate 分子名称: 1,2-ETHANEDIOL, METHOTREXATE, SERINE, ... 著者 Ruszkowski, M, Sekula, B, Dauter, Z. 登録日 2019-08-22 公開日 2020-01-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models. Sci Rep, 9, 2019
7TP4	Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody K398.22 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, K398.22 heavy chain, ... 著者 Yuan, M, Zhu, X, Wilson, I.A. 登録日 2022-01-24 公開日 2022-02-23 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques. Sci Transl Med, 14, 2022
9J0O	Arrested elongation complex of mammalian RNA polymerase II with nucleosome (AEC1-nuc) 分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB11-a, ... 著者 Naganuma, M, Kujirai, T, Ehara, H, Uejima, T, Ito, T, Goto, M, Aoki, M, Henmi, M, Miyamoto-Kohno, S, Shirouzu, M, Kurumizaka, H, Sekine, S. 登録日 2024-08-02 公開日 2025-02-05 最終更新日 2025-06-18 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural insights into promoter-proximal pausing of RNA polymerase II at +1 nucleosome. Sci Adv, 11, 2025
8S2E	Fab4251-DS-SOSIP complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... 著者 Nortier, P, Perez, L. 登録日 2024-02-17 公開日 2024-07-03 最終更新日 2025-07-09 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 RAIN: a Machine Learning-based identification for HIV-1 bNAbs. Res Sq, 2024
5YTX	Crystal structure of YB1 cold-shock domain in complex with UCAACU 分子名称: Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*UP*CP*AP*AP*CP*U)-3') 著者 Yang, X, Huang, Y. 登録日 2017-11-20 公開日 2018-12-05 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.551 Å) 主引用文献 Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA. J.Biol.Chem., 294, 2019
5AXW	Crystal structure of Staphylococcus aureus Cas9 in complex with sgRNA and target DNA (TTGGGT PAM) 分子名称: 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9, DNA (28-MER), ... 著者 Nishimasu, H, Ishitani, R, Nureki, O. 登録日 2015-08-01 公開日 2015-09-02 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal Structure of Staphylococcus aureus Cas9. Cell, 162, 2015
7C6G	Crystal structure of beta-glycosides-binding protein (W177X) of ABC transporter in an open-liganded state bound to gentiobiose 分子名称: 1,2-ETHANEDIOL, CARBON DIOXIDE, CHLORIDE ION, ... 著者 Kanaujia, S.P, Chandravanshi, M, Samanta, R. 登録日 2020-05-21 公開日 2020-10-21 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Conformational Trapping of a beta-Glucosides-Binding Protein Unveils the Selective Two-Step Ligand-Binding Mechanism of ABC Importers. J.Mol.Biol., 432, 2020
4EZ2	Crystal Structure of d(CCGGGACCGG)4 as a four-way junction at 1.6 angstrom resolution 分子名称: 5'-D(*CP*CP*GP*GP*GP*AP*CP*CP*GP*G)-3', SODIUM ION 著者 Chakraborty, A, Mandal, P.K, Gautham, N. 登録日 2012-05-02 公開日 2012-10-17 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure of d(CCGGGACCGG)(4) as a four-way junction at 1.6 A resolution: new insights into solvent interactions. Acta Crystallogr.,Sect.F, 68, 2012
3M6Y	Structure of 4-hydroxy-2-oxoglutarate aldolase from bacillus cereus at 1.45 a resolution. 分子名称: 4-Hydroxy-2-oxoglutarate aldolase, CALCIUM ION, CHLORIDE ION 著者 Filippova, E.V, Minasov, G, Shuvalova, L, Kiryukhina, O, Clancy, S, Joachimiak, A, Anderson, F.W, Midwest Center for Structural Genomics (MCSG) 登録日 2010-03-16 公開日 2010-04-07 最終更新日 2024-11-27 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structure of 4-Hydroxy-2-Oxoglutarate Aldolase from Bacillus Cereus at 1.45 A Resolution. To be Published
5B68	Crystal structure of apo amylomaltase from Corynebacterium glutamicum 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-alpha-glucanotransferase, GLYCEROL, ... 著者 Joo, S, Kim, S, Kim, K.-J. 登録日 2016-05-25 公開日 2016-08-03 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal Structure of Amylomaltase from Corynebacterium glutamicum. J.Agric.Food Chem., 64, 2016
6FT0	Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-425 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-{4-methoxy-3-[(2-methoxyphenyl)methoxy]phenyl}-2-(1-{thieno[3,2-d]pyrimidin-4-yl}piperidin-4-yl)-1,2,4a,5,8,8a-hexahydrophthalazin-1-one, ... 著者 Singh, A.K, Brown, D.G. 登録日 2018-02-20 公開日 2019-03-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 hPDE4D2 structure with inhibitor NPD-425 To be published
5VIU	Crystal Structure of Acetylornithine Aminotransferase from Elizabethkingia anophelis 分子名称: 1,2-ETHANEDIOL, Acetylornithine aminotransferase, CITRIC ACID 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2017-04-17 公開日 2017-05-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal Structure of Acetylornithine Aminotransferase from Elizabethkingia anophelis to be published
7TDJ	Rabbit RyR1 with AMP-PCP and high Ca2+ embedded in nanodisc in closed-inactivated conformation class 1(Dataset-A) 分子名称: CALCIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Ryanodine receptor 1,Ryanodine receptor 1,RyR1, ... 著者 Nayak, A.R, Samso, M. 登録日 2021-12-31 公開日 2022-03-09 最終更新日 2024-10-30 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Ca 2+ -inactivation of the mammalian ryanodine receptor type 1 in a lipidic environment revealed by cryo-EM. Elife, 11, 2022
5ENC	Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with N-(2,6-Dichlorobenzyl)acetamide (SGC - Diamond I04-1 fragment screening) 分子名称: 1,2-ETHANEDIOL, PH-interacting protein, ~{N}-[[2,6-bis(chloranyl)phenyl]methyl]ethanamide 著者 Krojer, T, Talon, R, Collins, P, Bradley, A, Cox, O, Szykowska, A, Burgess-Brown, N, Brennan, P, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F, Structural Genomics Consortium (SGC) 登録日 2015-11-09 公開日 2016-04-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain. Chem Sci, 7, 2016
9GPC	The crystal structure of ManDH5 E303Q mutant at 1.4 Angstroms Resolution - a beta-D-Mannanase of GH5 family from Dictyoglomus thermophilium 分子名称: DUF5060 domain-containing protein, GLYCEROL 著者 Sivron, Y, Romano, A, Shoham, Y, Shoham, G. 登録日 2024-09-07 公開日 2025-09-17 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 The crystal structure of ManDH5 E303Q mutant at 1.4 Angstroms Resolution - a beta-D-Mannanase of GH5 family from Dictyoglomus thermophilium To Be Published
5I3V	Crystal structure of BACE1 in complex with aminoquinoline compound 1 分子名称: (2R)-3-[2-amino-6-(3-methylpyridin-2-yl)quinolin-3-yl]-N-(3,3-dimethylbutyl)-2-methylpropanamide, Beta-secretase 1, GLYCEROL, ... 著者 Whittington, D.A, Long, A.M. 登録日 2016-02-11 公開日 2016-03-30 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Fragment-Linking Approach Using (19)F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of beta-Secretase. J.Med.Chem., 59, 2016
6FWU	Crystal structure of human wild type beta-1,4-galactosyltransferase-1 (B4GalT1) in apo-closed dimeric form 分子名称: Beta-1,4-galactosyltransferase 1, NITRATE ION 著者 Harrus, D, Kellokumpu, S, Glumoff, T. 登録日 2018-03-07 公開日 2018-10-10 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 The dimeric structure of wild-type human glycosyltransferase B4GalT1. PLoS ONE, 13, 2018
5BPY	Crystal structure of bruton agammaglobulinemia tyrosine kinase complexed with BMS-824171 AKA 6-[(3R)-3-(4-tert-bu tylbenzamido)piperidin-1-yl]-2-{[4-(morpholine-4-carbonyl) phenyl]amino}pyridine-3-carboxamide 分子名称: 6-{(3R)-3-[(4-tert-butylbenzoyl)amino]piperidin-1-yl}-2-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}pyridine-3-carboxamide, Tyrosine-protein kinase BTK 著者 Muckelbauer, J.K. 登録日 2015-05-28 公開日 2015-09-23 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton's tyrosine kinase (BTK) and Janus kinase 2 (JAK2). Bioorg.Med.Chem.Lett., 25, 2015
9GPE	ManDH5 E303Q in complex with mannotetraose after co-crystalliztion with mannotetraose at 1.6 angstroms resolution a beta-D-Mannanase of GH5 family from Dictyoglomus thermophilium 分子名称: DUF5060 domain-containing protein, beta-D-mannopyranose, beta-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-4)-beta-D-mannopyranose 著者 Sivron, Y, Romano, A, Shoham, Y, Shoham, G. 登録日 2024-09-07 公開日 2025-09-17 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 ManDH5 E303Q in complex with mannotetraose after co-crystalliztion with mannotetraose at 1.6 angstroms resolution a beta-D-Mannanase of GH5 family from Dictyoglomus thermophilium To Be Published
3K2H	Co-crystal structure of dihydrofolate reductase/thymidylate synthase from Babesia bovis with dUMP, Pemetrexed and NADP 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2009-09-30 公開日 2009-10-13 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis. Acta Crystallogr.,Sect.F, 67, 2011
7NQ7	C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH (S)-N-ethyl-3-(1-methyl-1H-1,2,3-triazol-4-yl)-4-(1-phenylethoxy)benzamide 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 2, ~{N}-ethyl-3-(1-methyl-1,2,3-triazol-4-yl)-4-[(1~{S})-1-phenylethoxy]benzamide 著者 Chung, C. 登録日 2021-03-01 公開日 2021-03-24 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors. J.Med.Chem., 64, 2021
5BNR	E. coli Fabh with small molecule inhibitor 2 分子名称: 1-{5-[2-fluoro-5-(hydroxymethyl)phenyl]pyridin-2-yl}piperidine-4-carboxylic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 3 著者 Kazmirski, S.L, McKinney, D.C. 登録日 2015-05-26 公開日 2016-05-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping. Acs Infect Dis., 2, 2016
8UGT	E. eligens beta-glucuronidase bound to UNC10206581-G 分子名称: 8-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5-(methylamino)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinoline, Beta-glucuronidase, GLYCEROL, ... 著者 Simpson, J.B, Redinbo, M.R. 登録日 2023-10-06 公開日 2024-07-24 最終更新日 2024-09-11 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Advanced piperazine-containing inhibitors target microbial beta-glucuronidases linked to gut toxicity. Rsc Chem Biol, 5, 2024

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