3K2H
Co-crystal structure of dihydrofolate reductase/thymidylate synthase from Babesia bovis with dUMP, Pemetrexed and NADP
Summary for 3K2H
Entry DOI | 10.2210/pdb3k2h/pdb |
Related | 3i3r |
Descriptor | Dihydrofolate reductase/thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, ... (6 entities in total) |
Functional Keywords | niaid, ssgcid, seattle structural genomics center for infectious disease, alimta, folic acid analog, thya, folate antimetabolites, tic-borne parasitic protozoan, babesiosis, malaria-like disease, methyltransferase, transferase |
Biological source | Babesia bovis |
Total number of polymer chains | 2 |
Total formula weight | 120690.47 |
Authors | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2009-09-30, release date: 2009-10-13, Last modification date: 2023-09-06) |
Primary citation | Begley, D.W.,Edwards, T.E.,Raymond, A.C.,Smith, E.R.,Hartley, R.C.,Abendroth, J.,Sankaran, B.,Lorimer, D.D.,Myler, P.J.,Staker, B.L.,Stewart, L.J. Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis. Acta Crystallogr.,Sect.F, 67:1070-1077, 2011 Cited by PubMed: 21904052DOI: 10.1107/S1744309111029009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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