6SMN
A. thaliana serine hydroxymethyltransferase isoform 2 (AtSHMT2) in complex with methotrexate
Summary for 6SMN
| Entry DOI | 10.2210/pdb6smn/pdb |
| Descriptor | Serine hydroxymethyltransferase 2, mitochondrial, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE, 1,2-ETHANEDIOL, ... (7 entities in total) |
| Functional Keywords | shmt, antifolate, transferase |
| Biological source | Arabidopsis thaliana (Mouse-ear cress) More |
| Total number of polymer chains | 4 |
| Total formula weight | 220319.08 |
| Authors | Ruszkowski, M.,Sekula, B.,Dauter, Z. (deposition date: 2019-08-22, release date: 2020-01-08, Last modification date: 2024-01-24) |
| Primary citation | Ruszkowski, M.,Sekula, B.,Ruszkowska, A.,Contestabile, R.,Nogues, I.,Angelaccio, S.,Szczepaniak, A.,Dauter, Z. Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models. Sci Rep, 9:19614-19614, 2019 Cited by PubMed: 31873125DOI: 10.1038/s41598-019-56043-4 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
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