6SMN
A. thaliana serine hydroxymethyltransferase isoform 2 (AtSHMT2) in complex with methotrexate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Serine hydroxymethyltransferase 2, mitochondrial | polymer | 480 | 53545.0 | 3 | UniProt (Q94C74) Pfam (PF00464) | Arabidopsis thaliana (Mouse-ear cress) | AtSHMT2,Glycine hydroxymethyltransferase 2,Serine methylase 2 |
| 2 | D (D) | Serine hydroxymethyltransferase 2, mitochondrial | polymer | 480 | 53773.2 | 1 | UniProt (Q94C74) Pfam (PF00464) | Arabidopsis thaliana (Mouse-ear cress) | AtSHMT2,Glycine hydroxymethyltransferase 2,Serine methylase 2 |
| 3 | E, HA, W (A, C, B) | [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE | non-polymer | 336.2 | 3 | Chemie (PLS) | |||
| 4 | AA, BA, BB, CA, CB... (B, D, A, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 48 | Chemie (EDO) | |||
| 5 | G, JA, XA, Y (A, C, B) | METHOTREXATE | non-polymer | 454.4 | 4 | Chemie (MTX) | |||
| 6 | AB (D) | SERINE | non-polymer | 105.1 | 1 | Chemie (SER) | |||
| 7 | IB, JB, KB, LB (A, B, C, D) | water | water | 18.0 | 1922 | Chemie (HOH) |
Sequence modifications
A, B, C: 41 - 517 (UniProt: Q94C74)
D: 41 - 517 (UniProt: Q94C74)
| PDB | External Database | Details |
|---|---|---|
| Ser 38 | - | expression tag |
| Asn 39 | - | expression tag |
| Ala 40 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 38 | - | expression tag |
| Asn 39 | - | expression tag |
| Ala 40 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 214408.3 | |
| Non-Polymers* | Number of molecules | 56 |
| Total formula weight | 5910.8 | |
| All* | Total formula weight | 220319.1 |
