5BNR
E. coli Fabh with small molecule inhibitor 2
Summary for 5BNR
| Entry DOI | 10.2210/pdb5bnr/pdb |
| Related | 5BNM 5BNS 5BQS |
| Descriptor | 3-oxoacyl-[acyl-carrier-protein] synthase 3, 1-{5-[2-fluoro-5-(hydroxymethyl)phenyl]pyridin-2-yl}piperidine-4-carboxylic acid (3 entities in total) |
| Functional Keywords | fabh, fatty acid synthesis, anti-bacterials, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Escherichia coli |
| Cellular location | Cytoplasm : P0A6R0 |
| Total number of polymer chains | 1 |
| Total formula weight | 33877.38 |
| Authors | Kazmirski, S.L.,McKinney, D.C. (deposition date: 2015-05-26, release date: 2016-05-18, Last modification date: 2024-03-06) |
| Primary citation | McKinney, D.C.,Eyermann, C.J.,Gu, R.F.,Hu, J.,Kazmirski, S.L.,Lahiri, S.D.,McKenzie, A.R.,Shapiro, A.B.,Breault, G. Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping. Acs Infect Dis., 2:456-464, 2016 Cited by PubMed: 27626097DOI: 10.1021/acsinfecdis.6b00053 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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