4E67
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![BU of 4e67 by Molmil](/molmil-images/mine/4e67) | The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with hydrocinnamoyl-derivatized PLHSpTA peptide | 分子名称: | Serine/threonine-protein kinase PLK1, hydrocinnamoyl-derivatized PLHSpTA peptide | 著者 | Sledz, P, Hyvonen, M, Tan, Y.S, Lang, S, Spring, D, Abell, C, Best, R.B. | 登録日 | 2012-03-15 | 公開日 | 2012-10-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1. Angew.Chem.Int.Ed.Engl., 51, 2012
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4E9C
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![BU of 4e9c by Molmil](/molmil-images/mine/4e9c) | The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with LDPPLHSpTA phosphopeptide | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, GLYCEROL, LDPPLHSpTA phosphopeptide, ... | 著者 | Sledz, P, Hyvonen, M, Lang, S, Stubbs, C.J, Abell, C. | 登録日 | 2012-03-21 | 公開日 | 2012-10-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | High-throughput interrogation of ligand binding mode using a fluorescence-based assay. Angew. Chem. Int. Ed. Engl., 51, 2012
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3P36
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![BU of 3p36 by Molmil](/molmil-images/mine/3p36) | Polo-like kinase I Polo-box domain in complex with DPPLHSpTA phosphopeptide from PBIP1 | 分子名称: | GLYCEROL, PHOSPHATE ION, Serine/threonine-protein kinase PLK1, ... | 著者 | Sledz, P, Stubbs, C.J, Hyvonen, M, Abell, C. | 登録日 | 2010-10-04 | 公開日 | 2011-04-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1 Angew.Chem.Int.Ed.Engl., 50, 2011
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3P2W
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3P34
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![BU of 3p34 by Molmil](/molmil-images/mine/3p34) | Polo-like kinase I Polo-box domain in complex with MQSpTPL phosphopeptide | 分子名称: | GLYCEROL, SULFATE ION, Serine/threonine-protein kinase PLK1, ... | 著者 | Sledz, P, Hyvonen, M, Abell, C. | 登録日 | 2010-10-04 | 公開日 | 2011-04-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1 Angew.Chem.Int.Ed.Engl., 50, 2011
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3P35
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3P37
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4DFW
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![BU of 4dfw by Molmil](/molmil-images/mine/4dfw) | Oxime-based Post Solid-phase Peptide Diversification: Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides | 分子名称: | CHLORIDE ION, Peptide, Serine/threonine-protein kinase PLK1 | 著者 | Liu, F, Park, J.-E, Qian, W.-J, Lim, D, Gr ber, M, Berg, T, Yaffe, M.B, Lee, K.S, Burke Jr, T.R. | 登録日 | 2012-01-24 | 公開日 | 2012-03-28 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Oxime-based Post Solid-phase Peptide Diversification: Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Chem.Biol., 2012
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3RQ7
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![BU of 3rq7 by Molmil](/molmil-images/mine/3rq7) | Polo-like kinase 1 Polo box domain in complex with a C6H5(CH2)8-derivatized peptide inhibitor | 分子名称: | C6H5(CH2)8-derivatized peptide inhibitor, Serine/threonine-protein kinase PLK1 | 著者 | Liu, F, Park, J.-E, Qian, W.-J, Lim, D.C, Graber, M, Berg, T, Yaffe, M.B, Lee, K.S, Burke Jr, T.R. | 登録日 | 2011-04-27 | 公開日 | 2011-07-20 | 最終更新日 | 2012-12-12 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel. Nat.Chem.Biol., 7, 2011
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4HCO
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4HAB
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![BU of 4hab by Molmil](/molmil-images/mine/4hab) | Crystal structure of Plk1 Polo-box domain in complex with PL-49 | 分子名称: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, PHOSPHATE ION, PL-49, ... | 著者 | Lee, W.C, Song, J.H, Kim, H.Y. | 登録日 | 2012-09-26 | 公開日 | 2013-04-03 | 最終更新日 | 2022-12-21 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1. Bioorg.Med.Chem., 21, 2013
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4H5X
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3P2Z
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![BU of 3p2z by Molmil](/molmil-images/mine/3p2z) | Polo-like kinase I Polo-box domain in complex with PLHSpTA phosphopeptide from PBIP1 | 分子名称: | GLYCEROL, Serine/threonine-protein kinase PLK1, phosphopeptide | 著者 | Sledz, P, Stubbs, C.J, Hyvonen, M, Abell, C. | 登録日 | 2010-10-04 | 公開日 | 2011-04-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1 Angew.Chem.Int.Ed.Engl., 50, 2011
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4H71
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![BU of 4h71 by Molmil](/molmil-images/mine/4h71) | Human Plk1-PBD in complex with Poloxime ((E)-4-(hydroxyimino)-2-isopropyl-5-methylcyclohexa-2,5-dienone) | 分子名称: | 2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione 1-oxime, GLYCEROL, Serine/threonine-protein kinase PLK1 | 著者 | Yin, Z, Rehse, P.H. | 登録日 | 2012-09-19 | 公開日 | 2012-10-03 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box
Domain As a Phosphate Mimic Acs Chem.Biol., 8, 2013
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5X3S
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5J19
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![BU of 5j19 by Molmil](/molmil-images/mine/5j19) | phospho-Pon binding-induced Plk1 dimerization | 分子名称: | GLYCEROL, Phosphorylated peptide from Partner of Numb, Serine/threonine-protein kinase PLK1 | 著者 | Zhu, K, Shan, Z, Zhang, L, Wen, W. | 登録日 | 2016-03-29 | 公開日 | 2016-06-15 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Phospho-Pon Binding-Mediated Fine-Tuning of Plk1 Activity Structure, 24, 2016
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6GY2
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8JOQ
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8S30
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8S31
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3BZI
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![BU of 3bzi by Molmil](/molmil-images/mine/3bzi) | Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization | 分子名称: | 9 mer peptide from M-phase inducer phosphatase 3, FORMIC ACID, Serine/threonine-protein kinase PLK1 | 著者 | Garcia-Alvarez, B, de Carcer, G, Ibanez, S, Bragado-Nilsson, E, Montoya, G. | 登録日 | 2008-01-18 | 公開日 | 2008-02-05 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization. Proc.Natl.Acad.Sci.Usa, 104, 2007
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5DMV
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5DNJ
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![BU of 5dnj by Molmil](/molmil-images/mine/5dnj) | Mouse Polo-box domain and Peptide analog 702 | 分子名称: | Serine/threonine-protein kinase PLK1, peptide 707-56A-SER-TPO-NH2 | 著者 | Namgoong, S, Han, Y.H. | 登録日 | 2015-09-10 | 公開日 | 2016-02-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization. Sci Rep, 5, 2015
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5DMS
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![BU of 5dms by Molmil](/molmil-images/mine/5dms) | Mouse Polo-box domain and Emi2 (169-177) | 分子名称: | F-box only protein 43, Serine/threonine-protein kinase PLK1 | 著者 | Namgoong, S. | 登録日 | 2015-09-09 | 公開日 | 2015-10-28 | 実験手法 | X-RAY DIFFRACTION (1.89999 Å) | 主引用文献 | Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization. Sci Rep, 5, 2015
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2OJX
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![BU of 2ojx by Molmil](/molmil-images/mine/2ojx) | Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization | 分子名称: | Serine/threonine-protein kinase PLK1, Synthetic peptide | 著者 | Garcia-Alvarez, B, de Carcer, G, Ibanez, S, Bragado-Nilsson, E, Montoya, G. | 登録日 | 2007-01-15 | 公開日 | 2007-02-13 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization. Proc.Natl.Acad.Sci.Usa, 104, 2007
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