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PDB: 76 件
4E67
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The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with hydrocinnamoyl-derivatized PLHSpTA peptide
分子名称: Serine/threonine-protein kinase PLK1, hydrocinnamoyl-derivatized PLHSpTA peptide
著者Sledz, P, Hyvonen, M, Tan, Y.S, Lang, S, Spring, D, Abell, C, Best, R.B.
登録日2012-03-15
公開日2012-10-10
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1.
Angew.Chem.Int.Ed.Engl., 51, 2012
4E9C
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The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with LDPPLHSpTA phosphopeptide
分子名称: 2-(2-METHOXYETHOXY)ETHANOL, GLYCEROL, LDPPLHSpTA phosphopeptide, ...
著者Sledz, P, Hyvonen, M, Lang, S, Stubbs, C.J, Abell, C.
登録日2012-03-21
公開日2012-10-10
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献High-throughput interrogation of ligand binding mode using a fluorescence-based assay.
Angew. Chem. Int. Ed. Engl., 51, 2012
3P36
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Polo-like kinase I Polo-box domain in complex with DPPLHSpTA phosphopeptide from PBIP1
分子名称: GLYCEROL, PHOSPHATE ION, Serine/threonine-protein kinase PLK1, ...
著者Sledz, P, Stubbs, C.J, Hyvonen, M, Abell, C.
登録日2010-10-04
公開日2011-04-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1
Angew.Chem.Int.Ed.Engl., 50, 2011
3P2W
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Unliganded form of Polo-like kinase I Polo-box domain
分子名称: GLYCEROL, SULFATE ION, Serine/threonine-protein kinase PLK1
著者Sledz, P, Hyvonen, M, Abell, C.
登録日2010-10-04
公開日2011-04-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1
Angew.Chem.Int.Ed.Engl., 50, 2011
3P34
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Polo-like kinase I Polo-box domain in complex with MQSpTPL phosphopeptide
分子名称: GLYCEROL, SULFATE ION, Serine/threonine-protein kinase PLK1, ...
著者Sledz, P, Hyvonen, M, Abell, C.
登録日2010-10-04
公開日2011-04-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1
Angew.Chem.Int.Ed.Engl., 50, 2011
3P35
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Polo-like kinase I Polo-box domain in complex with MQSpSPL phosphopeptide
分子名称: GLYCEROL, Serine/threonine-protein kinase PLK1, phosphopeptide
著者Sledz, P, Hyvonen, M, Abell, C.
登録日2010-10-04
公開日2011-04-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1
Angew.Chem.Int.Ed.Engl., 50, 2011
3P37
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Polo-like kinase I Polo-box domain in complex with FDPPLHSpTA phosphopeptide from PBIP1
分子名称: GLYCEROL, Serine/threonine-protein kinase PLK1, phosphopeptide
著者Sledz, P, Hyvonen, M, Abell, C.
登録日2010-10-04
公開日2011-04-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1
Angew.Chem.Int.Ed.Engl., 50, 2011
4DFW
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Oxime-based Post Solid-phase Peptide Diversification: Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides
分子名称: CHLORIDE ION, Peptide, Serine/threonine-protein kinase PLK1
著者Liu, F, Park, J.-E, Qian, W.-J, Lim, D, Gr ber, M, Berg, T, Yaffe, M.B, Lee, K.S, Burke Jr, T.R.
登録日2012-01-24
公開日2012-03-28
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Oxime-based Post Solid-phase Peptide Diversification: Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides
Chem.Biol., 2012
3RQ7
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Polo-like kinase 1 Polo box domain in complex with a C6H5(CH2)8-derivatized peptide inhibitor
分子名称: C6H5(CH2)8-derivatized peptide inhibitor, Serine/threonine-protein kinase PLK1
著者Liu, F, Park, J.-E, Qian, W.-J, Lim, D.C, Graber, M, Berg, T, Yaffe, M.B, Lee, K.S, Burke Jr, T.R.
登録日2011-04-27
公開日2011-07-20
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel.
Nat.Chem.Biol., 7, 2011
4HCO
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Human Plk1-PBD in complex with Thymoquinone at the phophopeptide binding site
分子名称: 2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione, GLYCEROL, Serine/threonine-protein kinase PLK1
著者Yin, Z, Rehse, P.H.
登録日2012-10-01
公開日2012-10-10
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic
Acs Chem.Biol., 8, 2013
4HAB
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Crystal structure of Plk1 Polo-box domain in complex with PL-49
分子名称: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, PHOSPHATE ION, PL-49, ...
著者Lee, W.C, Song, J.H, Kim, H.Y.
登録日2012-09-26
公開日2013-04-03
最終更新日2022-12-21
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1.
Bioorg.Med.Chem., 21, 2013
4H5X
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human Plk1-PBD with a glycerol bound at the phophopeptide binding site
分子名称: GLYCEROL, Serine/threonine-protein kinase PLK1
著者Yin, Z, Rehse, P.H.
登録日2012-09-19
公開日2012-10-03
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic
Acs Chem.Biol., 8, 2013
3P2Z
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BU of 3p2z by Molmil
Polo-like kinase I Polo-box domain in complex with PLHSpTA phosphopeptide from PBIP1
分子名称: GLYCEROL, Serine/threonine-protein kinase PLK1, phosphopeptide
著者Sledz, P, Stubbs, C.J, Hyvonen, M, Abell, C.
登録日2010-10-04
公開日2011-04-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1
Angew.Chem.Int.Ed.Engl., 50, 2011
4H71
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Human Plk1-PBD in complex with Poloxime ((E)-4-(hydroxyimino)-2-isopropyl-5-methylcyclohexa-2,5-dienone)
分子名称: 2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione 1-oxime, GLYCEROL, Serine/threonine-protein kinase PLK1
著者Yin, Z, Rehse, P.H.
登録日2012-09-19
公開日2012-10-03
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic
Acs Chem.Biol., 8, 2013
5X3S
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BU of 5x3s by Molmil
Crystal structure of mouse Plk1-PBD in complex with phosphopeptide from HEF1 (799-809)
分子名称: Peptide from Enhancer of filamentation 1, Serine/threonine-protein kinase PLK1
著者Kim, J.H, Shin, S.C, Kim, E.E.
登録日2017-02-07
公開日2017-12-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.899 Å)
主引用文献Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions.
J. Biol. Chem., 293, 2018
5J19
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BU of 5j19 by Molmil
phospho-Pon binding-induced Plk1 dimerization
分子名称: GLYCEROL, Phosphorylated peptide from Partner of Numb, Serine/threonine-protein kinase PLK1
著者Zhu, K, Shan, Z, Zhang, L, Wen, W.
登録日2016-03-29
公開日2016-06-15
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Phospho-Pon Binding-Mediated Fine-Tuning of Plk1 Activity
Structure, 24, 2016
6GY2
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Crystal structure of human Plk1-PBD in complex with WSSSLATPPTLSSpTVLI phosphopeptide from BRCA2
分子名称: GLYCEROL, Phosphopeptide of BRCA2, Serine/threonine-protein kinase PLK1
著者Miron, S, Ropars, V, Zinn-Justin, S.
登録日2018-06-28
公開日2019-07-10
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1.
Nat Commun, 11, 2020
8JOQ
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Plk1 polo-box domain bound to HPV18 L2 residues 209-215 with pThr213
分子名称: HPV18 L2 peptide, Serine/threonine-protein kinase PLK1
著者Ku, B, Jung, S.
登録日2023-06-08
公開日2023-10-11
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.796 Å)
主引用文献Crystal Structures of Plk1 Polo-Box Domain Bound to the Human Papillomavirus Minor Capsid Protein L2-Derived Peptide.
J.Microbiol, 61, 2023
8S30
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Crystal structure of human PLK1 Polo-Box Domain in complex with Mis18
分子名称: Protein Mis18-alpha, Serine/threonine-protein kinase PLK1
著者Jeyaprakash, A.A, Medina-Pritchard, B.
登録日2024-02-19
公開日2024-08-21
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献PLK1-mediated phosphorylation cascade activates Mis18 complex to ensure centromere inheritance
Science, 2024
8S31
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Crystal structure of human PLK1 Polo-Box Domain in complex with Mis18BP1
分子名称: Mis18-binding protein 1, Serine/threonine-protein kinase PLK1
著者Jeyaprakash, A.A, Medina-Pritchard, B.
登録日2024-02-19
公開日2024-08-21
実験手法X-RAY DIFFRACTION (2.134 Å)
主引用文献PLK1-mediated phosphorylation cascade activates Mis18 complex to ensure centromere inheritance
Science, 2024
3BZI
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Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization
分子名称: 9 mer peptide from M-phase inducer phosphatase 3, FORMIC ACID, Serine/threonine-protein kinase PLK1
著者Garcia-Alvarez, B, de Carcer, G, Ibanez, S, Bragado-Nilsson, E, Montoya, G.
登録日2008-01-18
公開日2008-02-05
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization.
Proc.Natl.Acad.Sci.Usa, 104, 2007
5DMV
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Polo-box domain of Mouse Polo-like kinase 1 complexed with Emi2 (146-177)
分子名称: F-box only protein 43, NICKEL (II) ION, Serine/threonine-protein kinase PLK1
著者Namgoong, S.
登録日2015-09-09
公開日2015-10-28
実験手法X-RAY DIFFRACTION (2.499 Å)
主引用文献Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization.
Sci Rep, 5, 2015
5DNJ
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Mouse Polo-box domain and Peptide analog 702
分子名称: Serine/threonine-protein kinase PLK1, peptide 707-56A-SER-TPO-NH2
著者Namgoong, S, Han, Y.H.
登録日2015-09-10
公開日2016-02-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization.
Sci Rep, 5, 2015
5DMS
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Mouse Polo-box domain and Emi2 (169-177)
分子名称: F-box only protein 43, Serine/threonine-protein kinase PLK1
著者Namgoong, S.
登録日2015-09-09
公開日2015-10-28
実験手法X-RAY DIFFRACTION (1.89999 Å)
主引用文献Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization.
Sci Rep, 5, 2015
2OJX
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Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization
分子名称: Serine/threonine-protein kinase PLK1, Synthetic peptide
著者Garcia-Alvarez, B, de Carcer, G, Ibanez, S, Bragado-Nilsson, E, Montoya, G.
登録日2007-01-15
公開日2007-02-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization.
Proc.Natl.Acad.Sci.Usa, 104, 2007

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