4HCO

Human Plk1-PBD in complex with Thymoquinone at the phophopeptide binding site

Replaces:  4H70Replaces:  3MQ8

Summary for 4HCO

• Entry DOI: 10.2210/pdb4hco/pdb
• Related: 4H5X 4H71
• Descriptor: Serine/threonine-protein kinase PLK1, GLYCEROL, 2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione, ... (4 entities in total)
• Functional Keywords: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P53350
• Total number of polymer chains: 2
• Total formula weight: 55345.04

Authors

Yin, Z.,Rehse, P.H. (deposition date: 2012-10-01, release date: 2012-10-10, Last modification date: 2023-11-08)

• Primary citation: Yin, Z.,Song, Y.,Rehse, P.H.; Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic; Acs Chem.Biol., 8:303-308, 2013; PubMed: 23135290; DOI: 10.1021/cb3004379

Experimental method

X-RAY DIFFRACTION (2.75 Å)