4HCO
Human Plk1-PBD in complex with Thymoquinone at the phophopeptide binding site
Replaces: 4H70Replaces: 3MQ8Summary for 4HCO
Entry DOI | 10.2210/pdb4hco/pdb |
Related | 4H5X 4H71 |
Descriptor | Serine/threonine-protein kinase PLK1, GLYCEROL, 2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione, ... (4 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P53350 |
Total number of polymer chains | 2 |
Total formula weight | 55345.04 |
Authors | Yin, Z.,Rehse, P.H. (deposition date: 2012-10-01, release date: 2012-10-10, Last modification date: 2023-11-08) |
Primary citation | Yin, Z.,Song, Y.,Rehse, P.H. Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic Acs Chem.Biol., 8:303-308, 2013 Cited by PubMed: 23135290DOI: 10.1021/cb3004379 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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