4HCO
Human Plk1-PBD in complex with Thymoquinone at the phophopeptide binding site
Replaces: 4H70Replaces: 3MQ8Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 701 |
| Chain | Residue |
| A | TRP414 |
| A | GLU460 |
| A | LEU490 |
| A | IMW702 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE IMW A 702 |
| Chain | Residue |
| A | LYS540 |
| A | ARG557 |
| A | GOL701 |
| A | HOH802 |
| A | HOH805 |
| A | GLU460 |
| A | LEU491 |
| A | ALA493 |
| A | ARG507 |
| A | HIS538 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976 |
| Chain | Residue | Details |
| B | SER375 | |
| B | SER450 | |
| A | SER375 | |
| A | SER450 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976 |
| Chain | Residue | Details |
| B | THR498 | |
| A | THR498 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23455478 |
| Chain | Residue | Details |
| B | LYS492 | |
| A | LYS492 |
