4HAB
Crystal structure of Plk1 Polo-box domain in complex with PL-49
Summary for 4HAB
Entry DOI | 10.2210/pdb4hab/pdb |
Related PRD ID | PRD_000780 |
Descriptor | Serine/threonine-protein kinase PLK1, PL-49, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ... (5 entities in total) |
Functional Keywords | polo-box domain, phosphoprotein-binding domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P53350 |
Total number of polymer chains | 6 |
Total formula weight | 81221.86 |
Authors | Lee, W.C.,Song, J.H.,Kim, H.Y. (deposition date: 2012-09-26, release date: 2013-04-03, Last modification date: 2022-12-21) |
Primary citation | Murugan, R.N.,Park, J.E.,Lim, D.,Ahn, M.,Cheong, C.,Kwon, T.,Nam, K.Y.,Choi, S.H.,Kim, B.Y.,Yoon, D.Y.,Yaffe, M.B.,Yu, D.Y.,Lee, K.S.,Bang, J.K. Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1. Bioorg.Med.Chem., 21:2623-2634, 2013 Cited by PubMed: 23498919DOI: 10.1016/j.bmc.2013.02.020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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