4HAB
Crystal structure of Plk1 Polo-box domain in complex with PL-49
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CXS A 601 |
| Chain | Residue |
| A | PHE436 |
| A | ASN437 |
| A | TRP514 |
| A | PHE515 |
| A | ARG516 |
| A | CXS602 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CXS A 602 |
| Chain | Residue |
| B | GLU504 |
| B | LEU505 |
| B | ALA506 |
| A | PHE515 |
| A | ARG516 |
| A | CXS601 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 603 |
| Chain | Residue |
| A | ASN385 |
| A | ARG584 |
| A | HOH704 |
| A | HOH725 |
| A | HOH726 |
| C | HIS538 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CXS B 601 |
| Chain | Residue |
| B | ASN437 |
| B | THR513 |
| B | TRP514 |
| B | PHE515 |
| B | ARG516 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CXS C 601 |
| Chain | Residue |
| B | LEU394 |
| B | VAL395 |
| C | PHE534 |
| C | SER578 |
| C | ARG581 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CXS C 602 |
| Chain | Residue |
| C | THR513 |
| C | TRP514 |
| C | ARG516 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 78 |
| Details | Domain: {"description":"POLO box 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00154","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 164 |
| Details | Domain: {"description":"POLO box 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00154","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | Region: {"description":"Linker"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Region: {"description":"Important for interaction with phosphorylated proteins","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23455478","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
