5X3S

Crystal structure of mouse Plk1-PBD in complex with phosphopeptide from HEF1 (799-809)

Summary for 5X3S

Entry DOI	10.2210/pdb5x3s/pdb
Descriptor	Serine/threonine-protein kinase PLK1, Peptide from Enhancer of filamentation 1 (3 entities in total)
Functional Keywords	polo like kinase 1, plk1, polo-box domain, hef1, transferase, transferase-peptide complex, transferase/peptide
Biological source	Mus musculus (Mouse) More
Cellular location	Nucleus : Q07832 Cytoplasm, cell cortex. Enhancer of filamentation 1 p55: Cytoplasm, cytoskeleton, spindle: Q14511
Total number of polymer chains	4
Total formula weight	54477.71
Authors	Kim, J.H.,Shin, S.C.,Kim, E.E. (deposition date: 2017-02-07, release date: 2017-12-20, Last modification date: 2023-11-22)
Primary citation	Lee, K.H.,Hwang, J.A.,Kim, S.O.,Kim, J.H.,Shin, S.C.,Kim, E.E.,Lee, K.S.,Rhee, K.,Jeon, B.H.,Bang, J.K.,Cha-Molstad, H.,Soung, N.K.,Jang, J.H.,Ko, S.K.,Lee, H.G.,Ahn, J.S.,Kwon, Y.T.,Kim, B.Y. Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions. J. Biol. Chem., 293:847-862, 2018 Cited by PubMed: 29191835 DOI: 10.1074/jbc.M117.802587 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.899 Å)

Structure validation