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PDB: 16 件
3BEA
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BU of 3bea by Molmil
cFMS tyrosine kinase (tie2 KID) in complex with a pyrimidinopyridone inhibitor
分子名称: 8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]phenyl}amino)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide, Macrophage colony-stimulating factor 1 receptor, SULFATE ION
著者Schubert, C.
登録日2007-11-16
公開日2008-07-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors.
Bioorg.Med.Chem.Lett., 18, 2008
6MWE
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BU of 6mwe by Molmil
CRYSTAL STRUCTURE OF TIE2 IN COMPLEX WITH DECIPERA COMPOUND DP1919
分子名称: 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, Angiopoietin-1 receptor, SULFATE ION
著者Chun, L, Abendroth, J, Edwards, T.E.
登録日2018-10-29
公開日2018-11-21
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2
Mol. Cancer Ther., 16, 2017
7E72
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BU of 7e72 by Molmil
Crystal structure of Tie2-agonistic antibody in complex with human Tie2 Fn2-3
分子名称: 1,2-ETHANEDIOL, Angiopoietin-1 receptor, the chimeric Fab fragment of 3H7 (heavy chain), ...
著者Kim, H.M, Jo, G.H, Hong, H.J, Han, A.
登録日2021-02-25
公開日2021-11-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.094 Å)
主引用文献Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody.
Nat Commun, 12, 2021
2OO8
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Synthesis, Structural Analysis, and SAR Studies of Triazine Derivatives as Potent, Selective Tie-2 Inhibitors
分子名称: Angiopoietin-1 receptor, N-{3-[3-(DIMETHYLAMINO)PROPYL]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]BENZAMIDE
著者Bellon, S.F, Kim, J.
登録日2007-01-25
公開日2007-03-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
1FVR
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BU of 1fvr by Molmil
TIE2 KINASE DOMAIN
分子名称: TYROSINE-PROTEIN KINASE TIE-2
著者Shewchuk, L.M, Hassell, A.M, Ellis, B, Holmes, W.D, Davis, R, Horne, E.L, Kadwell, S.H, McKee, D.D, Moore, J.T.
登録日2000-09-20
公開日2001-09-20
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail.
Structure Fold.Des., 8, 2000
3L8P
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BU of 3l8p by Molmil
Crystal structure of cytoplasmic kinase domain of Tie2 complexed with inhibitor CEP11207
分子名称: 2-methyl-11-(1-methylethyl)-8-[(2S)-tetrahydro-2H-pyran-2-yl]-2,11,12,13-tetrahydro-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one, Angiopoietin-1 receptor
著者Fedorov, A.A, Fedorov, E.V, Pauletti, D, Meyer, S.L, Hudkins, R.L, Almo, S.C.
登録日2010-01-03
公開日2010-10-06
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of cytoplasmic kinase domain of Tie2 complexed with inhibitor CEP11207
To be Published
4X3J
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BU of 4x3j by Molmil
Selection of fragments for kinase inhibitor design: decoration is key
分子名称: 1-[4-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea, Angiopoietin-1 receptor
著者Czodrowski, P, Hoelzemann, G, Barnickel, G, Greiner, H, Musil, D.
登録日2014-11-30
公開日2014-12-24
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Selection of fragments for kinase inhibitor design: decoration is key.
J.Med.Chem., 58, 2015
2P4I
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Evolution of a highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor
分子名称: 4-METHYL-3-({3-[2-(METHYLAMINO)PYRIMIDIN-4-YL]PYRIDIN-2-YL}OXY)-N-[2-MORPHOLIN-4-YL-5-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE, Angiopoietin-1 receptor
著者Bellon, S.F.
登録日2007-03-12
公開日2007-03-20
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.
J.Med.Chem., 50, 2007
5UTK
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Crystal structure of the membrane proximal three fibronectin type III (FNIII) domains of Tie2 (Tie2[FNIIIa-c])
分子名称: Angiopoietin-1 receptor
著者Moore, J.O, Lemmon, M.A, Ferguson, K.M.
登録日2017-02-15
公開日2017-04-12
最終更新日2019-12-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Dimerization of Tie2 mediated by its membrane-proximal FNIII domains.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5MYB
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BU of 5myb by Molmil
Homodimerization of Tie2 Fibronectin-like domains 2 and 3 in space group P21
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiopoietin-1 receptor, ...
著者Leppanen, V.-M, Saharinen, P, Alitalo, K.
登録日2017-01-26
公開日2017-04-26
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
2OSC
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BU of 2osc by Molmil
Synthesis, Structural Analysis, and SAR Studies of Triazine Derivatives as Potent, Selective Tie-2 Inhibitors
分子名称: Angiopoietin-1 receptor, N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE
著者Bellon, S.F, Kim, J.
登録日2007-02-05
公開日2007-03-20
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
5MYA
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BU of 5mya by Molmil
Homodimerization of Tie2 Fibronectin-like domains 1-3 in space group C2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiopoietin-1 receptor, ...
著者Leppanen, V.-M, Saharinen, P, Alitalo, K.
登録日2017-01-26
公開日2017-04-26
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
2GY5
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BU of 2gy5 by Molmil
Tie2 Ligand-Binding Domain Crystal Structure
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiopoietin-1 receptor, ...
著者Barton, W.A, Nikolov, D.B.
登録日2006-05-09
公開日2006-06-06
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex.
Nat.Struct.Mol.Biol., 13, 2006
2WQB
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BU of 2wqb by Molmil
Structure of the Tie2 kinase domain in complex with a thiazolopyrimidine inhibitor
分子名称: 2-[3-(CYCLOHEXYLMETHYL)-5-PHENYL-IMIDAZOL-4-YL]-[1,3]THIAZOLO[4,5-E]PYRIMIDIN-7-AMINE, ANGIOPOIETIN-1 RECEPTOR
著者Brassington, C, Breed, J, Buttar, D, Fitzek, M, Forder, C, Hassall, L, Hayter, B.R, Jones, C.D, Luke, R.W.A, McCall, E, McCoull, W, Norman, R, Paterson, D, McMiken, H, Rowsell, S, Tucker, J.A.
登録日2009-08-18
公開日2009-11-03
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Novel Thienopyrimidine and Thiazolopyrimidine Kinase Inhibitors with Activity Against Tie-2 in Vitro and in Vivo.
Bioorg.Med.Chem.Lett., 19, 2009
2GY7
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BU of 2gy7 by Molmil
Angiopoietin-2/Tie2 Complex Crystal Structure
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Barton, W.A, Nikolov, D.B.
登録日2006-05-09
公開日2006-06-06
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex.
Nat.Struct.Mol.Biol., 13, 2006
4K0V
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BU of 4k0v by Molmil
Structural basis for angiopoietin-1 mediated signaling initiation
分子名称: Angiopoietin-1, TEK tyrosine kinase variant
著者Yu, X, Seegar, T.C.M, Dalton, A.C, Tzvetkova-Robev, D, Goldgur, Y, Nikolov, D.B, Barton, W.A.
登録日2013-04-04
公開日2013-05-08
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (4.51 Å)
主引用文献Structural basis for angiopoietin-1-mediated signaling initiation.
Proc.Natl.Acad.Sci.USA, 110, 2013

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