2WQB

Structure of the Tie2 kinase domain in complex with a thiazolopyrimidine inhibitor

Summary for 2WQB

• Entry DOI: 10.2210/pdb2wqb/pdb
• Related: 1FVR 2GY5
• Descriptor: ANGIOPOIETIN-1 RECEPTOR, 2-[3-(CYCLOHEXYLMETHYL)-5-PHENYL-IMIDAZOL-4-YL]-[1,3]THIAZOLO[4,5-E]PYRIMIDIN-7-AMINE (3 entities in total)
• Functional Keywords: phosphoprotein, kinase, receptor, oncology, atp-binding, transferase, glycoprotein, tyrosine-protein kinase, phosphotransferase, nucleotide-binding, disease mutation, thiazolopyrimidine
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 37383.74

Authors

Brassington, C.,Breed, J.,Buttar, D.,Fitzek, M.,Forder, C.,Hassall, L.,Hayter, B.R.,Jones, C.D.,Luke, R.W.A.,McCall, E.,McCoull, W.,Norman, R.,Paterson, D.,McMiken, H.,Rowsell, S.,Tucker, J.A. (deposition date: 2009-08-18, release date: 2009-11-03, Last modification date: 2024-11-13)

Primary citation

Luke, R.W.,Ballard, P.,Buttar, D.,Campbell, L.,Curwen, J.,Emery, S.C.,Griffen, A.M.,Hassall, L.,Hayter, B.R.,Jones, C.D.,Mccoull, W.,Mellor, M.,Swain, M.L.,Tucker, J.A.
Novel Thienopyrimidine and Thiazolopyrimidine Kinase Inhibitors with Activity Against Tie-2 in Vitro and in Vivo.
Bioorg.Med.Chem.Lett., 19:6670-, 2009

PubMed Abstract: The SAR and improvement in potency against Tie2 of novel thienopyrimidine and thiazolopyrimidine kinase inhibitors are reported. The crystal structure of one of these compounds bound to the Tie-2 kinase domain is consistent with the SAR. These compounds have moderate potency in cellular assays of Tie-2 inhibition, good physical properties, DMPK, and show evidence of in vivo inhibition of Tie-2.

PubMed: 19854647
DOI: 10.1016/J.BMCL.2009.10.001

Experimental method

X-RAY DIFFRACTION (2.95 Å)