2WQB

Structure of the Tie2 kinase domain in complex with a thiazolopyrimidine inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE QQ1 A 2121

Chain	Residue
A	ALA853
A	LYS855
A	LEU900
A	ILE902
A	GLU903
A	TYR904
A	ALA905
A	ARG968
A	ASN969

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	26
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGNFGQVLkArikkdglrmd........AAIK

Chain	Residue	Details
A	ILE830-LYS855

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000305|PubMed:11080633

Chain	Residue	Details
A	ASN964

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	ILE830
A	LYS855

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site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:11513602

Chain	Residue	Details
A	TYR860
A	TYR992
A	TYR1108

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:14665640, ECO:0000269|PubMed:27270174

Chain	Residue	Details
A	TYR1102

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ARG968
A	ASN964

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