2WQB
Structure of the Tie2 kinase domain in complex with a thiazolopyrimidine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | ANGIOPOIETIN-1 RECEPTOR | polymer | 324 | 36993.2 | 1 | UniProt (Q02763) Pfam (PF07714) In PDB | HOMO SAPIENS (HUMAN) | TYROSINE-PROTEIN KINASE RECEPTOR TIE-2, TIE2 KINASE, TYROSINE-PROTEIN KINASE RECEPTOR TEK, TUNICA INTERNA ENDOTHELIAL CELL KINASE, P140 TEK, HTIE2 |
| 2 | A | 2-[3-(CYCLOHEXYLMETHYL)-5-PHENYL-IMIDAZOL-4-YL]-[1,3]THIAZOLO[4,5-E]PYRIMIDIN-7-AMINE | non-polymer | 390.5 | 1 | Chemie (QQ1) | |||
| 3 | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence modifications
A: 801 - 801 (PDB: 2WQB)
A: 802 - 1124 (UniProt: Q02763)
A: 802 - 1124 (UniProt: Q02763)
| PDB | External Database | Details |
|---|---|---|
| Asn 964 | Asp 964 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36993.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 390.5 | |
| All* | Total formula weight | 37383.7 |
