2P4I

Evolution of a highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor

Summary for 2P4I

• Entry DOI: 10.2210/pdb2p4i/pdb
• Related: 2oo8
• Descriptor: Angiopoietin-1 receptor, 4-METHYL-3-({3-[2-(METHYLAMINO)PYRIMIDIN-4-YL]PYRIDIN-2-YL}OXY)-N-[2-MORPHOLIN-4-YL-5-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE (3 entities in total)
• Functional Keywords: tie-2 kinase inhibitor triazine, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: Q02763
• Total number of polymer chains: 2
• Total formula weight: 73635.77

Authors

Bellon, S.F. (deposition date: 2007-03-12, release date: 2007-03-20, Last modification date: 2024-02-21)

• Primary citation: Hodous, B.L.,Geuns-Meyer, S.D.,Hughes, P.E.,Albrecht, B.K.,Bellon, S.,Bready, J.,Caenepeel, S.,Cee, V.J.,Chaffee, S.C.,Coxon, A.,Emery, M.,Fretland, J.,Gallant, P.,Gu, Y.,Hoffman, D.,Johnson, R.E.,Kendall, R.,Kim, J.L.,Long, A.M.,Morrison, M.,Olivieri, P.R.,Patel, V.F.,Polverino, A.,Rose, P.,Tempest, P.,Wang, L.,Whittington, D.A.,Zhao, H.; Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.; J.Med.Chem., 50:611-626, 2007; PubMed: 17253678; DOI: 10.1021/jm061107l

Experimental method

X-RAY DIFFRACTION (2.5 Å)