2P4I
Evolution of a highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Angiopoietin-1 receptor | polymer | 317 | 36253.3 | 2 | UniProt (Q02763) Pfam (PF07714) | Homo sapiens (human) | Tyrosine-protein kinase receptor TIE-2, hTIE2, Tyrosine-protein kinase receptor TEK, p140 TEK, Tunica interna endothelial cell kinase, CD202b antigen |
| 2 | C, D (A, B) | 4-METHYL-3-({3-[2-(METHYLAMINO)PYRIMIDIN-4-YL]PYRIDIN-2-YL}OXY)-N-[2-MORPHOLIN-4-YL-5-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE | non-polymer | 564.6 | 2 | Chemie (MR9) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 178 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72506.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1129.1 | |
| All* | Total formula weight | 73635.8 |
