2OO8
Synthesis, Structural Analysis, and SAR Studies of Triazine Derivatives as Potent, Selective Tie-2 Inhibitors
Summary for 2OO8
Entry DOI | 10.2210/pdb2oo8/pdb |
Descriptor | Angiopoietin-1 receptor, N-{3-[3-(DIMETHYLAMINO)PROPYL]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]BENZAMIDE (3 entities in total) |
Functional Keywords | kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: Q02763 |
Total number of polymer chains | 1 |
Total formula weight | 36787.90 |
Authors | Bellon, S.F.,Kim, J. (deposition date: 2007-01-25, release date: 2007-03-20, Last modification date: 2023-12-27) |
Primary citation | Hodous, B.L.,Geuns-Meyer, S.D.,Hughes, P.E.,Albrecht, B.K.,Bellon, S.,Caenepeel, S.,Cee, V.J.,Chaffee, S.C.,Emery, M.,Fretland, J.,Gallant, P.,Gu, Y.,Johnson, R.E.,Kim, J.L.,Long, A.M.,Morrison, M.,Olivieri, P.R.,Patel, V.F.,Polverino, A.,Rose, P.,Wang, L.,Zhao, H. Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors. Bioorg.Med.Chem.Lett., 17:2886-2889, 2007 Cited by PubMed: 17350837DOI: 10.1016/j.bmcl.2007.02.067 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report