2OO8
Synthesis, Structural Analysis, and SAR Studies of Triazine Derivatives as Potent, Selective Tie-2 Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | X | Angiopoietin-1 receptor | polymer | 317 | 36253.3 | 1 | UniProt (Q02763) Pfam (PF07714) In PDB | Homo sapiens (human) | Tyrosine-protein kinase receptor TIE-2, hTIE2, Tyrosine-protein kinase receptor TEK, p140 TEK, Tunica interna endothelial cell kinase, CD202b antigen |
| 2 | X | N-{3-[3-(DIMETHYLAMINO)PROPYL]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]BENZAMIDE | non-polymer | 534.6 | 1 | Chemie (RAJ) | |||
| 3 | water | water | 18.0 | 121 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36253.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 534.6 | |
| All* | Total formula weight | 36787.9 |
