3L8P
Crystal structure of cytoplasmic kinase domain of Tie2 complexed with inhibitor CEP11207
Summary for 3L8P
Entry DOI | 10.2210/pdb3l8p/pdb |
Related | 1FVR |
Descriptor | Angiopoietin-1 receptor, 2-methyl-11-(1-methylethyl)-8-[(2S)-tetrahydro-2H-pyran-2-yl]-2,11,12,13-tetrahydro-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (3 entities in total) |
Functional Keywords | receptor tyrosine kinase, cytoplasmic kinase domain, tie2, inhibitor cep11207, atp-binding, disease mutation, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: Q02763 |
Total number of polymer chains | 1 |
Total formula weight | 36705.88 |
Authors | Fedorov, A.A.,Fedorov, E.V.,Pauletti, D.,Meyer, S.L.,Hudkins, R.L.,Almo, S.C. (deposition date: 2010-01-03, release date: 2010-10-06, Last modification date: 2023-09-06) |
Primary citation | Fedorov, A.A.,Fedorov, E.V.,Pauletti, D.,Meyer, S.L.,Hudkins, R.L.,Almo, S.C. Crystal structure of cytoplasmic kinase domain of Tie2 complexed with inhibitor CEP11207 To be Published, |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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