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3L8P

Crystal structure of cytoplasmic kinase domain of Tie2 complexed with inhibitor CEP11207

Summary for 3L8P
Entry DOI10.2210/pdb3l8p/pdb
Related1FVR
DescriptorAngiopoietin-1 receptor, 2-methyl-11-(1-methylethyl)-8-[(2S)-tetrahydro-2H-pyran-2-yl]-2,11,12,13-tetrahydro-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (3 entities in total)
Functional Keywordsreceptor tyrosine kinase, cytoplasmic kinase domain, tie2, inhibitor cep11207, atp-binding, disease mutation, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, transferase, tyrosine-protein kinase
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: Q02763
Total number of polymer chains1
Total formula weight36705.88
Authors
Fedorov, A.A.,Fedorov, E.V.,Pauletti, D.,Meyer, S.L.,Hudkins, R.L.,Almo, S.C. (deposition date: 2010-01-03, release date: 2010-10-06, Last modification date: 2023-09-06)
Primary citationFedorov, A.A.,Fedorov, E.V.,Pauletti, D.,Meyer, S.L.,Hudkins, R.L.,Almo, S.C.
Crystal structure of cytoplasmic kinase domain of Tie2 complexed with inhibitor CEP11207
To be Published,
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

217705

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