3L8P
Crystal structure of cytoplasmic kinase domain of Tie2 complexed with inhibitor CEP11207
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Angiopoietin-1 receptor | polymer | 317 | 36253.3 | 1 | UniProt (Q02763) Pfam (PF07714) | Homo sapiens (human) | Tyrosine-protein kinase receptor TIE-2, hTIE2, Tyrosine-protein kinase receptor TEK, Tunica interna endothelial cell kinase, p140 TEK |
| 2 | B (A) | 2-methyl-11-(1-methylethyl)-8-[(2S)-tetrahydro-2H-pyran-2-yl]-2,11,12,13-tetrahydro-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one | non-polymer | 452.5 | 1 | Chemie (0CE) | |||
| 3 | C (A) | water | water | 18.0 | 39 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36253.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 452.5 | |
| All* | Total formula weight | 36705.9 |
