2OSC

Synthesis, Structural Analysis, and SAR Studies of Triazine Derivatives as Potent, Selective Tie-2 Inhibitors

Summary for 2OSC

• Entry DOI: 10.2210/pdb2osc/pdb
• Related: 2OO8
• Descriptor: Angiopoietin-1 receptor, N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE (3 entities in total)
• Functional Keywords: kinase domain tie-2, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane ; Single-pass type I membrane protein: Q02763
• Total number of polymer chains: 1
• Total formula weight: 36702.76

Authors

Bellon, S.F.,Kim, J. (deposition date: 2007-02-05, release date: 2007-03-20, Last modification date: 2024-02-21)

• Primary citation: Hodous, B.L.,Geuns-Meyer, S.D.,Hughes, P.E.,Albrecht, B.K.,Bellon, S.,Caenepeel, S.,Cee, V.J.,Chaffee, S.C.,Emery, M.,Fretland, J.,Gallant, P.,Gu, Y.,Johnson, R.E.,Kim, J.L.,Long, A.M.,Morrison, M.,Olivieri, P.R.,Patel, V.F.,Polverino, A.,Rose, P.,Wang, L.,Zhao, H.; Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors.; Bioorg.Med.Chem.Lett., 17:2886-2889, 2007; PubMed: 17350837; DOI: 10.1016/j.bmcl.2007.02.067

Experimental method

X-RAY DIFFRACTION (2.8 Å)