3BEA

cFMS tyrosine kinase (tie2 KID) in complex with a pyrimidinopyridone inhibitor

Summary for 3BEA

Entry DOI	10.2210/pdb3bea/pdb
Related	2I0v 2I0y 2I1m 2ogv
Descriptor	Macrophage colony-stimulating factor 1 receptor, SULFATE ION, 8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]phenyl}amino)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide, ... (4 entities in total)
Functional Keywords	kinase domain, inhibitor, transferase, juxtamembrane domain, atp-binding, glycoprotein, immunoglobulin domain, nucleotide-binding, phosphoprotein, polymorphism, proto-oncogene, receptor, transmembrane, tyrosine-protein kinase
Biological source	Homo sapiens (Human) More
Cellular location	Cell membrane; Single-pass type I membrane protein: P07333
Total number of polymer chains	1
Total formula weight	38452.94
Authors	Schubert, C. (deposition date: 2007-11-16, release date: 2008-07-15, Last modification date: 2023-08-30)
Primary citation	Huang, H.,Hutta, D.A.,Hu, H.,DesJarlais, R.L.,Schubert, C.,Petrounia, I.P.,Chaikin, M.A.,Manthey, C.L.,Player, M.R. Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors. Bioorg.Med.Chem.Lett., 18:2355-2361, 2008 Cited by PubMed: 18342505 DOI: 10.1016/j.bmcl.2008.02.070 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.02 Å)

Structure validation