3BEA

cFMS tyrosine kinase (tie2 KID) in complex with a pyrimidinopyridone inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Macrophage colony-stimulating factor 1 receptor	polymer	333	37655.1	1	UniProt (P07333) UniProt (Q02763) Pfam (PF07714)	Homo sapiens (Human)	CSF-1-R, Fms proto-oncogene, c-fms, CD115 antigen
2	B, C, D (A)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
3	E (A)	8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]phenyl}amino)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide	non-polymer		509.6	1	Chemie (IXH)
4	F (A)	water	water		18.0	169	Chemie (HOH)

Sequence modifications

A: 538 - 678 (UniProt: P07333)

PDB	External Database	Details
Gly 535	-	expression tag
Val 536	-	expression tag
Asp 537	-	expression tag

A: 753 - 922 (UniProt: P07333)
A: 679 - 697 (UniProt: Q02763)

PDB	External Database	Details
Leu 695	Ala 933	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	37655.1
Non-Polymers*	Number of molecules	4
	Total formula weight	797.8
All*	Total formula weight	38452.9

*Water molecules are not included.