5F1C
 
 | | Crystal structure of an invertebrate P2X receptor from the Gulf Coast tick in the presence of ATP and Zn2+ ion at 2.9 Angstroms | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Putative uncharacterized protein, ... | | 著者 | Kasuya, G, Hattori, M, Ishitani, R, Nureki, O. | | 登録日 | 2015-11-30 | | 公開日 | 2016-03-16 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural Insights into Divalent Cation Modulations of ATP-Gated P2X Receptor Channels
Cell Rep, 14, 2016
|
|
3H9V
 | | Crystal structure of the ATP-gated P2X4 ion channel in the closed, apo state at 3.1 Angstroms | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GADOLINIUM ATOM, P2X purinoceptor | | 著者 | Kawate, T, Michel, J.C, Gouaux, E. | | 登録日 | 2009-04-30 | | 公開日 | 2009-07-28 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Crystal structure of the ATP-gated P2X(4) ion channel in the closed state.
Nature, 460, 2009
|
|
4DW1
 | |
3I5D
 | | Crystal structure of the ATP-gated P2X4 ion channel in the closed, apo state at 3.5 Angstroms (R3) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, P2X purinoceptor | | 著者 | Kawate, T, Michel, J.C, Gouaux, E. | | 登録日 | 2009-07-05 | | 公開日 | 2009-08-04 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (3.46 Å) | | 主引用文献 | Crystal structure of the ATP-gated P2X(4) ion channel in the closed state.
Nature, 460, 2009
|
|
4DW0
 | |
9IK1
 | | Cryo-EM structure of the human P2X3 receptor-compound 26a complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[2-cyclopropyl-7-[[(1~{R})-1-naphthalen-2-ylethyl]amino]-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]piperazine-1-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Kim, S, Kim, G.R, Kim, Y.O, Han, X, Nagel, J, Kim, J, Song, D.I, Muller, C.E, Yoon, M.H, Jin, M.S, Kim, Y.C. | | 登録日 | 2024-06-26 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-11-27 | | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | | 主引用文献 | Discovery of Triazolopyrimidine Derivatives as Selective P2X3 Receptor Antagonists Binding to an Unprecedented Allosteric Site as Evidenced by Cryo-Electron Microscopy.
J.Med.Chem., 67, 2024
|
|
6AH5
 | |
6AH4
 | |
5YVE
 | |
9LXC
 | | Cryo-EM structure of the P2X1 receptor bound to NF449 | | 分子名称: | 4,4',4'',4'''-{carbonylbis[azanediylbenzene-5,1,3-triylbis(carbonylazanediyl)]}tetra(benzene-1,3-disulfonic acid), CHOLESTEROL, P2X purinoceptor 1 | | 著者 | Qiang, Y, Chen, K. | | 登録日 | 2025-02-17 | | 公開日 | 2025-04-16 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis of the multiple ligand binding mechanisms of the P2X1 receptor.
Acta Pharmacol.Sin., 2025
|
|
9LX5
 | |
5U1L
 | |
5U1V
 | |
5U1W
 | | Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist AZ10606120 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[2-({2-[(2-hydroxyethyl)amino]ethyl}amino)quinolin-5-yl]-2-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]acetamide, ... | | 著者 | Karasawa, A, Kawate, T. | | 登録日 | 2016-11-29 | | 公開日 | 2017-01-04 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (3.501 Å) | | 主引用文献 | Structural basis for subtype-specific inhibition of the P2X7 receptor.
Elife, 5, 2016
|
|
8JV5
 | |
8JV6
 | |
8JV7
 | | Cryo-EM structure of the panda P2X7 receptor in complex with PPADS | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(E)-[4-methanoyl-6-methyl-5-oxidanyl-3-(phosphonooxymethyl)pyridin-2-yl]diazenyl]benzene-1,3-disulfonic acid, P2X purinoceptor | | 著者 | Sheng, D, Hattori, M. | | 登録日 | 2023-06-27 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists.
Elife, 12, 2024
|
|
8JV8
 | | Cryo-EM structure of the panda P2X7 receptor in complex with PPNDS | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]-7-nitronaphthalene-1,5-disulfonic acid, P2X purinoceptor | | 著者 | Sheng, D, Hattori, M. | | 登録日 | 2023-06-27 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | | 主引用文献 | Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists.
Elife, 12, 2024
|
|
5WZY
 | | Crystal structure of the P2X4 receptor from zebrafish in the presence of CTP at 2.8 Angstroms | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CYTIDINE-5'-TRIPHOSPHATE, GLYCEROL, ... | | 著者 | Kasuya, G, Hattori, M, Nureki, O. | | 登録日 | 2017-01-19 | | 公開日 | 2017-04-05 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.799 Å) | | 主引用文献 | Structural insights into the nucleotide base specificity of P2X receptors
Sci Rep, 7, 2017
|
|
8Z1D
 | |
8Z0Z
 | | Cryo-EM structure of the panda P2X7 receptor in complex with JNJ-54175446 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, P2X purinoceptor, [2-chloranyl-3-(trifluoromethyl)phenyl]-[(4~{R})-1-(5-fluoranylpyrimidin-2-yl)-4-methyl-6,7-dihydro-4~{H}-[1,2,3]triazolo[4,5-c]pyridin-5-yl]methanone | | 著者 | Sheng, D, Hattori, M. | | 登録日 | 2024-04-10 | | 公開日 | 2025-04-16 | | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | | 主引用文献 | Cryo-EM structure of the panda P2X7 receptor in complex with JNJ-54175446
To Be Published
|
|
9C2C
 | | Cryo-EM structure of the human P2X1 receptor in the NF449-bound inhibited state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4,4',4'',4'''-{carbonylbis[azanediylbenzene-5,1,3-triylbis(carbonylazanediyl)]}tetra(benzene-1,3-disulfonic acid), P2X purinoceptor 1 | | 著者 | Oken, A.C, Lisi, N.E, Ditter, I.A, Shi, H, Mansoor, S.E. | | 登録日 | 2024-05-30 | | 公開日 | 2024-10-09 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Cryo-EM structures of the human P2X1 receptor reveal subtype-specific architecture and antagonism by supramolecular ligand-binding.
Nat Commun, 15, 2024
|
|
9C2B
 | | Cryo-EM structure of the human P2X1 receptor in the ATP-bound desensitized state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Oken, A.C, Lisi, N.E, Ditter, I.A, Shi, H, Mansoor, S.E. | | 登録日 | 2024-05-30 | | 公開日 | 2024-10-09 | | 最終更新日 | 2025-05-14 | | 実験手法 | ELECTRON MICROSCOPY (2.42 Å) | | 主引用文献 | Cryo-EM structures of the human P2X1 receptor reveal subtype-specific architecture and antagonism by supramolecular ligand-binding.
Nat Commun, 15, 2024
|
|
9C2A
 | | Cryo-EM structure of the human P2X1 receptor in the apo closed state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Oken, A.C, Lisi, N.E, Ditter, I.A, Shi, H, Mansoor, S.E. | | 登録日 | 2024-05-30 | | 公開日 | 2024-10-09 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | | 主引用文献 | Cryo-EM structures of the human P2X1 receptor reveal subtype-specific architecture and antagonism by supramolecular ligand-binding.
Nat Commun, 15, 2024
|
|
9C48
 | | Cryo-EM structure of the full-length human P2X4 receptor in the ATP-bound desensitized state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Shi, H, Ditter, I.A, Oken, A.C, Mansoor, S.E. | | 登録日 | 2024-06-03 | | 公開日 | 2025-01-29 | | 最終更新日 | 2025-05-14 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | Human P2X4 receptor gating is modulated by a stable cytoplasmic cap and a unique allosteric pocket.
Sci Adv, 11, 2025
|
|
