9C2C
Cryo-EM structure of the human P2X1 receptor in the NF449-bound inhibited state
This is a non-PDB format compatible entry.
Summary for 9C2C
Entry DOI | 10.2210/pdb9c2c/pdb |
Related | 9C2A 9C2B |
EMDB information | 45152 45153 45154 |
Descriptor | P2X purinoceptor 1, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4,4',4'',4'''-{carbonylbis[azanediylbenzene-5,1,3-triylbis(carbonylazanediyl)]}tetra(benzene-1,3-disulfonic acid) (3 entities in total) |
Functional Keywords | membrane protein, ion channel, ligand-gated ion channel, p2x receptor, allosteric antagonist |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 145083.16 |
Authors | Oken, A.C.,Lisi, N.E.,Ditter, I.A.,Shi, H.,Mansoor, S.E. (deposition date: 2024-05-30, release date: 2024-10-09) |
Primary citation | Oken, A.C.,Lisi, N.E.,Ditter, I.A.,Shi, H.,Nechiporuk, N.A.,Mansoor, S.E. Cryo-EM structures of the human P2X1 receptor reveal subtype-specific architecture and antagonism by supramolecular ligand-binding. Nat Commun, 15:8490-8490, 2024 Cited by PubMed: 39353889DOI: 10.1038/s41467-024-52636-4 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.9 Å) |
Structure validation
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