Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

9C2C

Cryo-EM structure of the human P2X1 receptor in the NF449-bound inhibited state

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001614molecular_functionpurinergic nucleotide receptor activity
A0002554biological_processserotonin secretion by platelet
A0003056biological_processregulation of vascular associated smooth muscle contraction
A0004931molecular_functionextracellularly ATP-gated monoatomic cation channel activity
A0005216molecular_functionmonoatomic ion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006915biological_processapoptotic process
A0006940biological_processregulation of smooth muscle contraction
A0007165biological_processsignal transduction
A0007320biological_processinsemination
A0008217biological_processregulation of blood pressure
A0009897cellular_componentexternal side of plasma membrane
A0015267molecular_functionchannel activity
A0016020cellular_componentmembrane
A0019228biological_processneuronal action potential
A0019229biological_processregulation of vasoconstriction
A0019722biological_processcalcium-mediated signaling
A0030168biological_processplatelet activation
A0030667cellular_componentsecretory granule membrane
A0032991cellular_componentprotein-containing complex
A0033198biological_processresponse to ATP
A0034220biological_processmonoatomic ion transmembrane transport
A0035249biological_processsynaptic transmission, glutamatergic
A0035579cellular_componentspecific granule membrane
A0035590biological_processpurinergic nucleotide receptor signaling pathway
A0042802molecular_functionidentical protein binding
A0043270biological_processpositive regulation of monoatomic ion transport
A0043924molecular_functionsuramin binding
A0044877molecular_functionprotein-containing complex binding
A0045121cellular_componentmembrane raft
A0045211cellular_componentpostsynaptic membrane
A0046513biological_processceramide biosynthetic process
A0048787cellular_componentpresynaptic active zone membrane
A0051649biological_processestablishment of localization in cell
A0051924biological_processregulation of calcium ion transport
A0060079biological_processexcitatory postsynaptic potential
A0070588biological_processcalcium ion transmembrane transport
A0098655biological_processmonoatomic cation transmembrane transport
A0098978cellular_componentglutamatergic synapse
A0099509biological_processregulation of presynaptic cytosolic calcium ion concentration
A0099604molecular_functionligand-gated calcium channel activity
A1905665biological_processpositive regulation of calcium ion import across plasma membrane
A2000300biological_processregulation of synaptic vesicle exocytosis
B0000166molecular_functionnucleotide binding
B0001614molecular_functionpurinergic nucleotide receptor activity
B0002554biological_processserotonin secretion by platelet
B0003056biological_processregulation of vascular associated smooth muscle contraction
B0004931molecular_functionextracellularly ATP-gated monoatomic cation channel activity
B0005216molecular_functionmonoatomic ion channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006915biological_processapoptotic process
B0006940biological_processregulation of smooth muscle contraction
B0007165biological_processsignal transduction
B0007320biological_processinsemination
B0008217biological_processregulation of blood pressure
B0009897cellular_componentexternal side of plasma membrane
B0015267molecular_functionchannel activity
B0016020cellular_componentmembrane
B0019228biological_processneuronal action potential
B0019229biological_processregulation of vasoconstriction
B0019722biological_processcalcium-mediated signaling
B0030168biological_processplatelet activation
B0030667cellular_componentsecretory granule membrane
B0032991cellular_componentprotein-containing complex
B0033198biological_processresponse to ATP
B0034220biological_processmonoatomic ion transmembrane transport
B0035249biological_processsynaptic transmission, glutamatergic
B0035579cellular_componentspecific granule membrane
B0035590biological_processpurinergic nucleotide receptor signaling pathway
B0042802molecular_functionidentical protein binding
B0043270biological_processpositive regulation of monoatomic ion transport
B0043924molecular_functionsuramin binding
B0044877molecular_functionprotein-containing complex binding
B0045121cellular_componentmembrane raft
B0045211cellular_componentpostsynaptic membrane
B0046513biological_processceramide biosynthetic process
B0048787cellular_componentpresynaptic active zone membrane
B0051649biological_processestablishment of localization in cell
B0051924biological_processregulation of calcium ion transport
B0060079biological_processexcitatory postsynaptic potential
B0070588biological_processcalcium ion transmembrane transport
B0098655biological_processmonoatomic cation transmembrane transport
B0098978cellular_componentglutamatergic synapse
B0099509biological_processregulation of presynaptic cytosolic calcium ion concentration
B0099604molecular_functionligand-gated calcium channel activity
B1905665biological_processpositive regulation of calcium ion import across plasma membrane
B2000300biological_processregulation of synaptic vesicle exocytosis
C0000166molecular_functionnucleotide binding
C0001614molecular_functionpurinergic nucleotide receptor activity
C0002554biological_processserotonin secretion by platelet
C0003056biological_processregulation of vascular associated smooth muscle contraction
C0004931molecular_functionextracellularly ATP-gated monoatomic cation channel activity
C0005216molecular_functionmonoatomic ion channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006915biological_processapoptotic process
C0006940biological_processregulation of smooth muscle contraction
C0007165biological_processsignal transduction
C0007320biological_processinsemination
C0008217biological_processregulation of blood pressure
C0009897cellular_componentexternal side of plasma membrane
C0015267molecular_functionchannel activity
C0016020cellular_componentmembrane
C0019228biological_processneuronal action potential
C0019229biological_processregulation of vasoconstriction
C0019722biological_processcalcium-mediated signaling
C0030168biological_processplatelet activation
C0030667cellular_componentsecretory granule membrane
C0032991cellular_componentprotein-containing complex
C0033198biological_processresponse to ATP
C0034220biological_processmonoatomic ion transmembrane transport
C0035249biological_processsynaptic transmission, glutamatergic
C0035579cellular_componentspecific granule membrane
C0035590biological_processpurinergic nucleotide receptor signaling pathway
C0042802molecular_functionidentical protein binding
C0043270biological_processpositive regulation of monoatomic ion transport
C0043924molecular_functionsuramin binding
C0044877molecular_functionprotein-containing complex binding
C0045121cellular_componentmembrane raft
C0045211cellular_componentpostsynaptic membrane
C0046513biological_processceramide biosynthetic process
C0048787cellular_componentpresynaptic active zone membrane
C0051649biological_processestablishment of localization in cell
C0051924biological_processregulation of calcium ion transport
C0060079biological_processexcitatory postsynaptic potential
C0070588biological_processcalcium ion transmembrane transport
C0098655biological_processmonoatomic cation transmembrane transport
C0098978cellular_componentglutamatergic synapse
C0099509biological_processregulation of presynaptic cytosolic calcium ion concentration
C0099604molecular_functionligand-gated calcium channel activity
C1905665biological_processpositive regulation of calcium ion import across plasma membrane
C2000300biological_processregulation of synaptic vesicle exocytosis
Functional Information from PROSITE/UniProt
site_idPS01212
Number of Residues27
DetailsP2X_RECEPTOR ATP P2X receptors signature. GGvVGItIdWhCDLDwhvrhCrPiYeF
ChainResidueDetails
AGLY250-PHE276

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues201
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P56373
ChainResidueDetails
AMET1-LYS28
ALYS359-SER399
CMET1-LYS28
CLYS359-SER399
BMET1-LYS28
BLYS359-SER399

site_idSWS_FT_FI2
Number of Residues63
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
AVAL29-LEU50
CVAL29-LEU50
BVAL29-LEU50

site_idSWS_FT_FI3
Number of Residues861
DetailsTOPO_DOM: Extracellular => ECO:0000250|UniProtKB:P56373
ChainResidueDetails
ATYR51-GLY338
CTYR51-GLY338
BTYR51-GLY338

site_idSWS_FT_FI4
Number of Residues57
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
AILE339-PRO358
CILE339-PRO358
BILE339-PRO358

site_idSWS_FT_FI5
Number of Residues21
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:F8W463
ChainResidueDetails
ALYS68
CLYS140
CTHR186
CASN290
CARG292
CLYS309
BLYS68
BLYS70
BLYS140
BTHR186
BASN290
ALYS70
BARG292
BLYS309
ALYS140
ATHR186
AASN290
AARG292
ALYS309
CLYS68
CLYS70

site_idSWS_FT_FI6
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P56373
ChainResidueDetails
ASER286
CSER286
BSER286

site_idSWS_FT_FI7
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:22971236
ChainResidueDetails
ASER387
ASER388
CSER387
CSER388
BSER387
BSER388

site_idSWS_FT_FI8
Number of Residues3
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:22971236
ChainResidueDetails
ATHR389
CTHR389
BTHR389

site_idSWS_FT_FI9
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN153
BASN184
BASN242
BASN300
AASN184
AASN242
AASN300
CASN153
CASN184
CASN242
CASN300
BASN153

237735

PDB entries from 2025-06-18

PDB statisticsPDBj update infoContact PDBjnumon