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PDB: 189 件
3SKK
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Crystal structure of human arginase I in complex with the inhibitor FABH, Resolution 1.70 A, twinned structure
分子名称: Arginase-1, MANGANESE (II) ION, [(5S)-5-amino-5-carboxy-6,6-difluorohexyl](trihydroxy)borate(1-)
著者Thorn, K.J, Di Costanzo, L, Christianson, D.W.
登録日2011-06-22
公開日2011-07-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.701 Å)
主引用文献Binding of alpha , alpha-disubstituted amino acids to arginase suggests new avenues for inhibitor design.
J.Med.Chem., 54, 2011
7ESR
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Crystal structure of Synechocystis sp PCC6803 guanidinium hydrolase (R32)
分子名称: 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ...
著者Mayans, O.M, Fleming, J.R.
登録日2021-05-11
公開日2021-12-15
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Discovery of a Ni 2+ -dependent guanidine hydrolase in bacteria.
Nature, 603, 2022
7EUN
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BU of 7eun by Molmil
Crystal structure of N(omega)-hydroxy-L-arginine hydrolase in complex with ABH
分子名称: 2(S)-AMINO-6-BORONOHEXANOIC ACID, MAGNESIUM ION, MANGANESE (II) ION, ...
著者Oda, K, Matoba, Y.
登録日2021-05-18
公開日2022-05-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Catalytic mechanism of DcsB: Arginase framework used for hydrolyzing its inhibitor.
Protein Sci., 31, 2022
7EUQ
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BU of 7euq by Molmil
Crystal structure of C86H-Y124N-G126H-H196S mutant of N(omega)-hydroxy-L-arginine hydrolase
分子名称: MAGNESIUM ION, MANGANESE (II) ION, N(omega)-hydroxy-L-arginine amidinohydrolase
著者Oda, K, Matoba, Y.
登録日2021-05-18
公開日2022-05-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Catalytic mechanism of DcsB: Arginase framework used for hydrolyzing its inhibitor.
Protein Sci., 31, 2022
7EUL
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Crystal structure of C86H-H196S mutant of N(omega)-hydroxy-L-arginine hydrolase
分子名称: MAGNESIUM ION, MANGANESE (II) ION, N(omega)-hydroxy-L-arginine amidinohydrolase
著者Oda, K, Matoba, Y.
登録日2021-05-18
公開日2022-05-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Catalytic mechanism of DcsB: Arginase framework used for hydrolyzing its inhibitor.
Protein Sci., 31, 2022
7EUK
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Crystal structure of N(omega)-hydroxy-L-arginine hydrolase in complex with L-Orn
分子名称: L-ornithine, MAGNESIUM ION, MANGANESE (II) ION, ...
著者Oda, K, Matoba, Y.
登録日2021-05-18
公開日2022-05-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Catalytic mechanism of DcsB: Arginase framework used for hydrolyzing its inhibitor.
Protein Sci., 31, 2022
7K4I
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Human Arginase 1 in complex with compound 06.
分子名称: 3-[(1~{S},2~{S},5~{R})-2-carboxy-6-thia-3-azabicyclo[3.2.0]heptan-1-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boranuide, Arginase-1, MANGANESE (II) ION
著者Palte, R.L.
登録日2020-09-15
公開日2021-10-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.
Acs Med.Chem.Lett., 12, 2021
7K4H
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Human Arginase 1 in complex with compound 04.
分子名称: 3-[(1~{R},5~{S},8~{R})-5-carboxy-2,6-diazabicyclo[3.2.1]octan-8-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boranuide, Arginase-1, MANGANESE (II) ION
著者Palte, R.L.
登録日2020-09-15
公開日2021-12-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.
Acs Med.Chem.Lett., 12, 2021
7K4J
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Human Arginase 1 in complex with compound 51.
分子名称: 3-[(1~{S},2~{S},5~{R})-2-carboxy-3,6-diazabicyclo[3.2.0]heptan-1-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boranuide, Arginase-1, MANGANESE (II) ION
著者Palte, R.L.
登録日2020-09-15
公開日2021-12-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.
Acs Med.Chem.Lett., 12, 2021
7K4G
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BU of 7k4g by Molmil
Human Arginase 1 in complex with compound 01.
分子名称: 3-[(2~{S},3~{R})-2-carboxypyrrolidin-3-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boranuide, Arginase-1, MANGANESE (II) ION
著者Palte, R.L.
登録日2020-09-15
公開日2021-12-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.
Acs Med.Chem.Lett., 12, 2021
7K4K
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Human Arginase 1 in complex with compound 52.
分子名称: 3-[(3~{a}~{S},4~{S},6~{a}~{R})-4-carboxy-2,3,4,5,6,6~{a}-hexahydro-1~{H}-pyrrolo[2,3-c]pyrrol-3~{a}-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boranuide, Arginase-1, MANGANESE (II) ION
著者Palte, R.L.
登録日2020-09-15
公開日2021-12-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.
Acs Med.Chem.Lett., 12, 2021
1T4S
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BU of 1t4s by Molmil
arginase-L-valine complex
分子名称: Arginase 1, MANGANESE (II) ION, VALINE
著者Cama, E, Pethe, S, Boucher, J.-L, Shoufa, H, Emig, F.A, Ash, D.E, Viola, R.E, Mansuy, D, Christianson, D.W.
登録日2004-04-30
公開日2004-10-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Inhibitor coordination interactions in the binuclear manganese cluster of arginase
Biochemistry, 43, 2004
1T4R
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BU of 1t4r by Molmil
arginase-descarboxy-nor-NOHA complex
分子名称: 3-{[(E)-AMINO(HYDROXYIMINO)METHYL]AMINO}PROPAN-1-AMINIUM, Arginase 1, MANGANESE (II) ION
著者Cama, E, Pethe, S, Boucher, J.-L, Shoufa, H, Emig, F.A, Ash, D.E, Viola, R.E, Mansuy, D, Christianson, D.W.
登録日2004-04-30
公開日2005-04-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Inhibitor coordination interactions in the binuclear manganese cluster of arginase
Biochemistry, 43, 2004
7KLM
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BU of 7klm by Molmil
Human Arginase1 Complexed with Inhibitor Compound 24a
分子名称: 3-[(2~{S},3~{R},4~{R})-4-[[(2~{S})-2-azanyl-3-methyl-butanoyl]amino]-2-carboxy-pyrrolidin-3-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boron, Arginase-1, MANGANESE (II) ION
著者Palte, R.L.
登録日2020-10-30
公開日2021-09-29
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.
Acs Med.Chem.Lett., 12, 2021
7KLL
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BU of 7kll by Molmil
Human Arginase1 Complexed with Inhibitor Compound 18
分子名称: 3-[(2~{S},3~{R},4~{R})-4-azanyl-2-carboxy-pyrrolidin-3-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boron, Arginase-1, MANGANESE (II) ION
著者Palte, R.L.
登録日2020-10-30
公開日2021-09-29
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.
Acs Med.Chem.Lett., 12, 2021
7KLK
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BU of 7klk by Molmil
Human Arginase1 Complexed with Inhibitor Compound 3a
分子名称: 1,2-ETHANEDIOL, 3-[(2~{S},3~{R})-2-carboxypiperidin-3-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boranuide, Arginase-1, ...
著者Palte, R.L.
登録日2020-10-30
公開日2021-09-29
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.801 Å)
主引用文献Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.
Acs Med.Chem.Lett., 12, 2021
7LEZ
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BU of 7lez by Molmil
Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:2 mAb1 complex
分子名称: Arginase-1, MANGANESE (II) ION, mAb1 heavy chain, ...
著者Gomez-Llorente, Y, Scapin, G, Palte, R.L.
登録日2021-01-15
公開日2021-09-01
実験手法ELECTRON MICROSCOPY (4.15 Å)
主引用文献Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.
Commun Biol, 4, 2021
7LEX
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BU of 7lex by Molmil
Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:3 mAb1 complex
分子名称: Arginase-1, mAb1 heavy chain, mAb1 light chain
著者Gomez-Llorente, Y, Scapin, G, Palte, R.L.
登録日2021-01-15
公開日2021-09-01
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.
Commun Biol, 4, 2021
7LEY
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BU of 7ley by Molmil
Trimeric human Arginase 1 in complex with mAb5
分子名称: Arginase-1, MANGANESE (II) ION, mAb5 heavy chain, ...
著者Gomez-Llorente, Y, Scapin, G, Palte, R.L.
登録日2021-01-15
公開日2021-09-01
実験手法ELECTRON MICROSCOPY (3.05 Å)
主引用文献Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.
Commun Biol, 4, 2021
7LF0
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BU of 7lf0 by Molmil
Trimeric human Arginase 1 in complex with mAb2
分子名称: Arginase-1, mAb2 heavy chain, mAb2 light chain
著者Gomez-Llorente, Y, Scapin, G, Palte, R.L.
登録日2021-01-15
公開日2021-09-01
実験手法ELECTRON MICROSCOPY (3.68 Å)
主引用文献Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.
Commun Biol, 4, 2021
7LF2
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Trimeric human Arginase 1 in complex with mAb4
分子名称: Arginase-1, MANGANESE (II) ION, mAb4 monoclonal antibody heavy chain, ...
著者Gomez-Llorente, Y, Scapin, G, Palte, R.L.
登録日2021-01-15
公開日2021-09-01
実験手法ELECTRON MICROSCOPY (3.72 Å)
主引用文献Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.
Commun Biol, 4, 2021
7LF1
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BU of 7lf1 by Molmil
Trimeric human Arginase 1 in complex with mAb3
分子名称: Arginase-1, MANGANESE (II) ION, mAb3 heavy chain, ...
著者Gomez-Llorente, Y, Scapin, G, Palte, R.L.
登録日2021-01-15
公開日2021-09-01
実験手法ELECTRON MICROSCOPY (4.04 Å)
主引用文献Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.
Commun Biol, 4, 2021
1R1O
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BU of 1r1o by Molmil
Amino Acid Sulfonamides as Transition-State Analogue Inhibitors of Arginase
分子名称: Arginase 1, MANGANESE (II) ION, S-[2-(AMINOSULFONYL)ETHYL]-D-CYSTEINE
著者Cama, E, Shin, H, Christianson, D.W.
登録日2003-09-24
公開日2003-10-28
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Design of Amino Acid Sulfonamides as Transition-State Analogue Inhibitors of Arginase
J.Am.Chem.Soc., 125, 2003
1T4P
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BU of 1t4p by Molmil
Arginase-dehydro-ABH complex
分子名称: Arginase 1, MANGANESE (II) ION, [(1E,5S)-5-AMINO-5-CARBOXYPENT-1-ENYL](TRIHYDROXY)BORATE(1-)
著者Cama, E, Pethe, S, Boucher, J.-L, Han, S, Emig, F.A, Ash, D.E, Viola, R.E, Mansuy, D, Christianson, D.W.
登録日2004-04-30
公開日2005-04-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Inhibitor coordination interactions in the binuclear manganese cluster of arginase
Biochemistry, 43, 2004
7LOX
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BU of 7lox by Molmil
The structure of Agmatinase from E. Coli at 3.2 A displaying guanidine in the active site
分子名称: Agmatinase, GUANIDINE, MANGANESE (II) ION
著者Maturana, P, Figueroa, M, Gonzalez-Ordenes, F, Villalobos, P, Martinez-Oyanedel, J, Uribe, E.A, Castro-Fernandez, V.
登録日2021-02-11
公開日2021-05-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal Structure of Escherichia coli Agmatinase: Catalytic Mechanism and Residues Relevant for Substrate Specificity.
Int J Mol Sci, 22, 2021

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