2IUE
| |
6DJP
| Integrin alpha-v beta-8 in complex with the Fabs 8B8 and 68 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 68 heavy chain Fab, ... | 著者 | Cormier, A, Campbell, M.G, Nishimura, S.L, Cheng, Y. | 登録日 | 2018-05-25 | 公開日 | 2018-07-25 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Cryo-EM structure of the alpha v beta 8 integrin reveals a mechanism for stabilizing integrin extension. Nat. Struct. Mol. Biol., 25, 2018
|
|
4CAK
| Three-dimensional reconstruction of intact human integrin alphaIIbbeta3 in a phospholipid bilayer nanodisc | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin alpha-IIb, ... | 著者 | Choi, W.S, Rice, W.J, Stokes, D.L, Coller, B.S. | 登録日 | 2013-10-08 | 公開日 | 2013-10-30 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (20.5 Å) | 主引用文献 | Three-Dimensional Reconstruction of Intact Human Integrin Alphaiibbeta3; New Implications for Activation-Dependent Ligand Binding. Blood, 122, 2013
|
|
5HDB
| Integrin alphaIIbbeta3 in complex with Ro-435054 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Lin, F.Y. | 登録日 | 2016-01-05 | 公開日 | 2016-02-03 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.7012 Å) | 主引用文献 | beta-Subunit Binding Is Sufficient for Ligands to Open the Integrin alpha IIb beta 3 Headpiece. J.Biol.Chem., 291, 2016
|
|
8IJ5
| |
6OM2
| |
2P26
| Structure of the PHE2 and PHE3 fragments of the integrin beta2 subunit | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin beta-2 | 著者 | Shi, M, Foo, S.Y, Tan, S.M, Mitchell, E.P, Law, S.K.A, Lescar, J. | 登録日 | 2007-03-06 | 公開日 | 2007-08-14 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | A structural hypothesis for the transition between bent and extended conformations of the leukocyte beta2 integrins J.Biol.Chem., 282, 2007
|
|
7L8P
| Integrin alphaIIbbeta3 in complex with sibrafiban | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Lin, F.-Y, Springer, T.A. | 登録日 | 2020-12-31 | 公開日 | 2022-06-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.34995365 Å) | 主引用文献 | A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185, 2022
|
|
4G1E
| Crystal structure of integrin alpha V beta 3 with coil-coiled tag. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Dong, X, Mi, L, Zhu, J, Wang, W, Luo, B, Springer, T.A. | 登録日 | 2012-07-10 | 公開日 | 2012-12-12 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | AlphaV Beta3 Integrin Crystal Structures and their Functional Implications Biochemistry, 51, 2012
|
|
4G1M
| Re-refinement of alpha V beta 3 structure | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Springer, T.A, Mi, L, Zhu, J. | 登録日 | 2012-07-10 | 公開日 | 2012-12-12 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Alpha V Beta 3 Integrin Crystal Structures and their Functional Implications Biochemistry, 51, 2012
|
|
5FFG
| Crystal structure of integrin alpha V beta 6 head | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Dong, X, Springer, T.A. | 登録日 | 2015-12-18 | 公開日 | 2017-01-25 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Force interacts with macromolecular structure in activation of TGF-beta. Nature, 542, 2017
|
|
7TCT
| Integrin alaphIIBbeta3 complex with UR2922 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Zhu, J, Lin, F.-Y, Zhu, J, Springer, T.A. | 登録日 | 2021-12-28 | 公開日 | 2022-08-17 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185, 2022
|
|
7CEB
| |
7TD8
| Integrin alaphIIBbeta3 complex with Tirofiban | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Zhu, J, Lin, F.-Y, Zhu, J, Springer, T.A. | 登録日 | 2021-12-30 | 公開日 | 2022-08-17 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185, 2022
|
|
1U8C
| A novel adaptation of the integrin PSI domain revealed from its crystal structure | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Xiong, J.P, Stehle, T, Goodman, S.L, Arnaout, M.A. | 登録日 | 2004-08-05 | 公開日 | 2004-12-28 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | A novel adaptation of the integrin PSI domain revealed from its crystal structure. J.Biol.Chem., 279, 2004
|
|
3FCU
| Structure of headpiece of integrin aIIBb3 in open conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, CALCIUM ION, ... | 著者 | Zhu, J, Luo, B.-H, Xiao, T, Zhang, C, Nishida, N, Springer, T.A. | 登録日 | 2008-11-22 | 公開日 | 2009-01-20 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces. Mol.Cell, 32, 2008
|
|
4UM9
| Crystal structure of alpha V beta 6 with peptide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Dong, X, Springer, T.A. | 登録日 | 2014-05-15 | 公開日 | 2014-11-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Determinants of Integrin Beta-Subunit Specificity for Latent Tgf-Beta Nat.Struct.Mol.Biol., 21, 2014
|
|
4UM8
| Crystal structure of alpha V beta 6 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, ... | 著者 | Dong, X, Springer, T.A. | 登録日 | 2014-05-15 | 公開日 | 2014-11-12 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.852 Å) | 主引用文献 | Structural Determinants of Integrin Beta-Subunit Specificity for Latent Tgf-Beta Nat.Struct.Mol.Biol., 21, 2014
|
|
3FCS
| Structure of complete ectodomain of integrin aIIBb3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Zhu, J, Luo, B.-H, Xiao, T, Zhang, C, Nishida, N, Springer, T.A. | 登録日 | 2008-11-22 | 公開日 | 2009-01-20 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces. Mol.Cell, 32, 2008
|
|
4O02
| AlphaVBeta3 integrin in complex with monoclonal antibody FAB fragment. | 分子名称: | 17E6 heavy chain, 17E6 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Mahalingam, B, van Agthoven, J, Xiong, J, Arnaout, M.A. | 登録日 | 2013-12-13 | 公開日 | 2014-04-02 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.605 Å) | 主引用文献 | Atomic basis for the species-specific inhibition of alpha V integrins by monoclonal antibody 17E6 is revealed by the crystal structure of alpha V beta 3 ectodomain-17E6 Fab complex. J.Biol.Chem., 289, 2014
|
|
3T3P
| A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Zhu, J, Zhu, J, Springer, T.A. | 登録日 | 2011-07-25 | 公開日 | 2012-03-28 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS Sci Transl Med, 4, 2012
|
|
1TYE
| Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, CALCIUM ION, ... | 著者 | Xiao, T, Takagi, J, Coller, B.S, Wang, J.-H, Springer, T.A. | 登録日 | 2004-07-07 | 公開日 | 2004-10-12 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics Nature, 432, 2004
|
|
3T3M
| A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Zhu, J, Zhu, J, Springer, T.A. | 登録日 | 2011-07-25 | 公開日 | 2012-03-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS Sci Transl Med, 4, 2012
|
|
6V4P
| Structure of the integrin AlphaIIbBeta3-Abciximab complex | 分子名称: | Abciximab, heavy chain, light chain, ... | 著者 | Nesic, D, Zhang, Y, Spasic, A, Li, J, Provasi, D, Filizola, M, Walz, T, Coller, B.S. | 登録日 | 2019-11-28 | 公開日 | 2020-02-05 | 最終更新日 | 2020-03-11 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Cryo-Electron Microscopy Structure of the alpha IIb beta 3-Abciximab Complex. Arterioscler Thromb Vasc Biol., 40, 2020
|
|
4Z7O
| Integrin alphaIIbbeta3 in complex with AGDV peptide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Lin, F.Y, Zhu, J, Springer, T.A. | 登録日 | 2015-04-07 | 公開日 | 2016-01-27 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | beta-Subunit Binding Is Sufficient for Ligands to Open the Integrin alpha IIb beta 3 Headpiece. J.Biol.Chem., 291, 2016
|
|