7L8P

Integrin alphaIIbbeta3 in complex with sibrafiban

Summary for 7L8P

• Entry DOI: 10.2210/pdb7l8p/pdb
• Descriptor: Isoform 3 of Integrin alpha-IIb, CALCIUM ION, MAGNESIUM ION, ... (15 entities in total)
• Functional Keywords: cell adhesion, platelet aggregation, membrane protein-immune system complex, integrin inhibitor, rgd mimetics
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 302474.58

Authors

Lin, F.-Y.,Springer, T.A. (deposition date: 2020-12-31, release date: 2022-06-15, Last modification date: 2023-10-25)

• Primary citation: Lin, F.Y.,Li, J.,Xie, Y.,Zhu, J.,Huong Nguyen, T.T.,Zhang, Y.,Zhu, J.,Springer, T.A.; A general chemical principle for creating closure-stabilizing integrin inhibitors.; Cell, 185:3533-3550.e27, 2022; PubMed: 36113427; DOI: 10.1016/j.cell.2022.08.008

Experimental method

X-RAY DIFFRACTION (2.3499537016 Å)