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PDB: 1515 件

6GMQ
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BU of 6gmq by Molmil
pVHL:EloB:EloC in complex with (4-(1H-pyrrol-1-yl)phenyl)methanol
分子名称: (4-pyrrol-1-ylphenyl)methanol, ACETATE ION, Elongin-B, ...
著者Van Molle, I, Lucas, X, Ciulli, A.
登録日2018-05-28
公開日2018-08-22
最終更新日2018-09-05
実験手法X-RAY DIFFRACTION (2.755 Å)
主引用文献Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.
J. Med. Chem., 61, 2018
6GFY
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BU of 6gfy by Molmil
pVHL:EloB:EloC in complex with modified VH032 containing (3R,4S)-3-fluoro-4-hydroxyproline (ligand 14a)
分子名称: (2~{R},3~{R},4~{S})-1-[(2~{S})-2-acetamido-3,3-dimethyl-butanoyl]-3-fluoranyl-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
著者Gadd, M.S, Testa, A, Ciulli, A.
登録日2018-05-02
公開日2018-07-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation.
J. Am. Chem. Soc., 140, 2018
8FY0
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BU of 8fy0 by Molmil
E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL)
分子名称: Bcl-2-like protein 1, CACODYLIC ACID, Elongin-B, ...
著者Olsen, S.K, Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D.
登録日2023-01-25
公開日2024-04-10
実験手法X-RAY DIFFRACTION (2.94 Å)
主引用文献Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
Nat Commun, 15, 2024
8FTQ
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BU of 8ftq by Molmil
Crystal structure of hRpn13 Pru domain in complex with Ubiquitin and XL44
分子名称: N-(3-{[(3R)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-yl]methyl}phenyl)-4-methoxybenzamide, Proteasomal ubiquitin receptor ADRM1, Ubiquitin
著者Walters, K.J, Lu, X, Chandravanshi, M.
登録日2023-01-13
公開日2024-03-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A structure-based designed small molecule depletes hRpn13 Pru and a select group of KEN box proteins.
Nat Commun, 15, 2024
8FY1
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BU of 8fy1 by Molmil
E3:PROTAC:target ternary complex structure (VCB/753b/BCL-2)
分子名称: Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ...
著者Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K.
登録日2023-01-25
公開日2024-04-10
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
Nat Commun, 15, 2024
8FY2
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BU of 8fy2 by Molmil
E3:PROTAC:target ternary complex structure (VCB/WH244/BCL-2)
分子名称: Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ...
著者Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Ruben, E, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K.
登録日2023-01-25
公開日2024-04-10
実験手法X-RAY DIFFRACTION (2.98 Å)
主引用文献Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
Nat Commun, 15, 2024
6GMN
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BU of 6gmn by Molmil
pVHL:EloB:EloC in complex with methyl 4H-furo[3,2-b]pyrrole-5-carboxylate
分子名称: ACETATE ION, Elongin-B, Elongin-C, ...
著者Van Molle, I, Lucas, X, Ciulli, A.
登録日2018-05-27
公開日2018-08-08
最終更新日2018-09-05
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.
J. Med. Chem., 61, 2018
6GMR
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BU of 6gmr by Molmil
pVHL:EloB:EloC in complex with (4-(1H-pyrrol-1-yl)phenyl)methanol
分子名称: (4-pyrrol-1-ylphenyl)methanol, Elongin-B, Elongin-C, ...
著者Van Molle, I, Lucas, X, Ciulli, A.
登録日2018-05-28
公開日2018-08-08
最終更新日2018-09-05
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.
J. Med. Chem., 61, 2018
6FMK
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BU of 6fmk by Molmil
pVHL:EloB:EloC in complex with N-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamothioyl) pyrrolidin-1-yl)-1-thioxopropan-2-yl)acetamide (ligand 4)
分子名称: Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ...
著者Soares, P, Lucas, X, Ciulli, A.
登録日2018-01-31
公開日2018-04-11
最終更新日2018-06-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.
Bioorg. Med. Chem., 26, 2018
6FNN
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BU of 6fnn by Molmil
Caldiarchaeum Subterraneum Ubiquitin:Rpn11-homolog complex
分子名称: 26S proteasome regulatory subunit N11-like protein, SULFATE ION, Ubiquitin-like protein, ...
著者Fuchs, A.C.D, Albrecht, R, Martin, J, Hartmann, M.D.
登録日2018-02-04
公開日2018-07-25
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Rpn11-mediated ubiquitin processing in an ancestral archaeal ubiquitination system.
Nat Commun, 9, 2018
6FX4
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BU of 6fx4 by Molmil
Disulfide between E3 HECT ligase Smurf2 and Ubiquitin G76C
分子名称: E3 ubiquitin-protein ligase SMURF2, GLYCEROL, Polyubiquitin-B
著者Jaeckl, M, Holdermann, I, Wiesner, S.
登録日2018-03-08
公開日2018-07-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献beta-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation.
J. Mol. Biol., 430, 2018
6GLC
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BU of 6glc by Molmil
Structure of phospho-Parkin bound to phospho-ubiquitin
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, E3 ubiquitin-protein ligase parkin, GLYCEROL, ...
著者Gladkova, C, Maslen, S.L, Skehel, J.M, Komander, D.
登録日2018-05-23
公開日2018-06-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Mechanism of parkin activation by PINK1.
Nature, 559, 2018
6GZS
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BU of 6gzs by Molmil
Structure of Chlamydia trachomatis effector protein ChlaDUB1 bound to ubiquitin
分子名称: Deubiquitinase and deneddylase Dub1, GLYCEROL, Polyubiquitin-B, ...
著者Pruneda, J.N, Komander, D.
登録日2018-07-05
公開日2018-11-14
最終更新日2018-12-05
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation.
Nat Microbiol, 3, 2018
3TMP
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BU of 3tmp by Molmil
The catalytic domain of human deubiquitinase DUBA in complex with ubiquitin aldehyde
分子名称: OTU domain-containing protein 5, Polyubiquitin-C
著者Ma, X, Yin, J, Hymowitz, S, Starovasnik, M, Cochran, A.
登録日2011-08-31
公開日2012-01-11
最終更新日2012-02-29
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Phosphorylation-dependent activity of the deubiquitinase DUBA.
Nat.Struct.Mol.Biol., 19, 2012
3V6E
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BU of 3v6e by Molmil
Crystal Structure of USP2 and a mutant form of Ubiquitin
分子名称: CHLORIDE ION, GLYCEROL, Ubiquitin, ...
著者Neculai, M, Ernst, A, Sidhu, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2011-12-19
公開日2012-12-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
3VAW
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BU of 3vaw by Molmil
Crystal structure of a smt fusion peptidyl-prolyl cis-trans isomerase with surface mutation v3i from burkholderia pseudomallei complexed with fk506
分子名称: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, Ubiquitin-like protein SMT3,Peptidyl-prolyl cis-trans isomerase
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2011-12-29
公開日2012-01-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.
Antimicrob.Agents Chemother., 58, 2014
3VUW
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BU of 3vuw by Molmil
Crystal structure of A20 ZF7 in complex with linear ubiquitin, form I
分子名称: POTASSIUM ION, Polyubiquitin-C, Tumor necrosis factor alpha-induced protein 3, ...
著者Nishimasu, H, Ishitani, R, Nureki, O.
登録日2012-07-09
公開日2013-02-13
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-kappaB regulation
Embo J., 31, 2012
7AY2
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BU of 7ay2 by Molmil
Crystal structure of truncated USP1-UAF1 reacted with ubiquitin-prg
分子名称: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 1, WD repeat-containing protein 48, ...
著者Arkinson, C, Rennie, M.L, Walden, H.
登録日2020-11-10
公開日2021-03-24
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Nat.Struct.Mol.Biol., 28, 2021
7AY1
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BU of 7ay1 by Molmil
Cryo-EM structure of USP1-UAF1 bound to mono-ubiquitinated FANCD2, and FANCI
分子名称: DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ...
著者Rennie, M.L, Arkinson, C, Walden, H.
登録日2020-11-10
公開日2021-03-24
最終更新日2022-07-27
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Nat.Struct.Mol.Biol., 28, 2021
7ZF1
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BU of 7zf1 by Molmil
Structure of ubiquitinated FANCI in complex with FANCD2 and double-stranded DNA
分子名称: DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ...
著者Lemonidis, K, Rennie, M.L, Arkinson, C, Streetley, J, Clarke, M, Chaugule, V.K, Walden, H.
登録日2022-03-31
公開日2022-11-16
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (4.14 Å)
主引用文献Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination.
Embo J., 42, 2023
3VUX
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BU of 3vux by Molmil
Crystal structure of A20 ZF7 in complex with linear ubiquitin, form II
分子名称: 1,2-ETHANEDIOL, POTASSIUM ION, Polyubiquitin-C, ...
著者Nishimasu, H, Ishitani, R, Nureki, O.
登録日2012-07-09
公開日2013-02-13
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.699 Å)
主引用文献Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-kappaB regulation
Embo J., 31, 2012
3WXG
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BU of 3wxg by Molmil
Crystal structure of CYLD USP domain (C596A) in complex with Lys63-linked diubiquitin
分子名称: Ubiquitin, Uncharacterized protein
著者Sato, Y, Fukai, S.
登録日2014-07-30
公開日2015-02-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity.
Nat.Struct.Mol.Biol., 22, 2015
7YUI
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BU of 7yui by Molmil
Crystal structure of HOIL-1L(195-423) in complex with the linear tetra-ubiquitin
分子名称: Polyubiquitin-C, RanBP-type and C3HC4-type zinc finger-containing protein 1, ZINC ION
著者Xiao, L, Pan, L.
登録日2022-08-17
公開日2023-08-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.599 Å)
主引用文献Mechanistic insights into the enzymatic activity of E3 ligase HOIL-1L and its regulation by the linear ubiquitin chain binding.
Sci Adv, 9, 2023
3V62
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BU of 3v62 by Molmil
Structure of the S. cerevisiae Srs2 C-terminal domain in complex with PCNA conjugated to SUMO on lysine 164
分子名称: ATP-dependent DNA helicase SRS2, N-ETHYLMALEIMIDE, Proliferating cell nuclear antigen, ...
著者Armstrong, A.A, Mohideen, F, Lima, C.D.
登録日2011-12-18
公開日2012-02-29
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2.
Nature, 483, 2012
7ZNT
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BU of 7znt by Molmil
CRYSTAL STRUCTURE OF AT7 IN COMPLEX WITH THE SECOND BROMODOMAIN OF HUMAN BRD4 AND PVHL:ELONGINC:ELONGINB
分子名称: (2~{S},4~{R})-1-[(2~{R})-3-[6-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]hexylsulfanyl]-2-[(1-fluoranylcyclopropyl)carbonylamino]-3-methyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Bromodomain-containing protein 4, Elongin-B, ...
著者Hughes, S.J, Casement, R, Ciulli, A.
登録日2022-04-22
公開日2022-09-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders.
Nat.Chem.Biol., 19, 2023

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件を2024-07-31に公開中

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