7ZNT

CRYSTAL STRUCTURE OF AT7 IN COMPLEX WITH THE SECOND BROMODOMAIN OF HUMAN BRD4 AND PVHL:ELONGINC:ELONGINB

Summary for 7ZNT

Entry DOI	10.2210/pdb7znt/pdb
Descriptor	Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (6 entities in total)
Functional Keywords	protac ternary complex, e3 ligase, protac, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	115004.70
Authors	Hughes, S.J.,Casement, R.,Ciulli, A. (deposition date: 2022-04-22, release date: 2022-09-14, Last modification date: 2024-02-07)
Primary citation	Hanzl, A.,Casement, R.,Imrichova, H.,Hughes, S.J.,Barone, E.,Testa, A.,Bauer, S.,Wright, J.,Brand, M.,Ciulli, A.,Winter, G.E. Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders. Nat.Chem.Biol., 19:323-333, 2023 Cited by PubMed: 36329119 DOI: 10.1038/s41589-022-01177-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation