7ZNT
CRYSTAL STRUCTURE OF AT7 IN COMPLEX WITH THE SECOND BROMODOMAIN OF HUMAN BRD4 AND PVHL:ELONGINC:ELONGINB
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | Elongin-B | polymer | 104 | 11748.4 | 2 | UniProt (Q15370) Pfam (PF00240) In PDB | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
2 | B, E | Elongin-C | polymer | 97 | 10974.6 | 2 | UniProt (Q15369) Pfam (PF03931) In PDB | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
3 | C, F | von Hippel-Lindau disease tumor suppressor | polymer | 162 | 18702.3 | 2 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) In PDB | Homo sapiens (human) | Protein G7,pVHL |
4 | G, H | Bromodomain-containing protein 4 | polymer | 130 | 15060.3 | 2 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (human) | Protein HUNK1 |
5 | C, F | (2~{S},4~{R})-1-[(2~{R})-3-[6-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]hexylsulfanyl]-2-[(1-fluoranylcyclopropyl)carbonylamino]-3-methyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide | non-polymer | 1016.7 | 2 | Chemie (IZR) | |||
6 | water | water | 18.0 | 32 | Chemie (HOH) |
Sequence modifications
B, E: 17 - 112 (UniProt: Q15369)
C, F: 54 - 213 (UniProt: P40337)
G, H: 333 - 460 (UniProt: O60885)
PDB | External Database | Details |
---|---|---|
Met 16 | - | initiating methionine |
PDB | External Database | Details |
---|---|---|
Gly 52 | - | expression tag |
Ser 53 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 331 | - | expression tag |
Met 332 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 112971.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 2033.4 | |
All* | Total formula weight | 115004.7 |