6GFY

pVHL:EloB:EloC in complex with modified VH032 containing (3R,4S)-3-fluoro-4-hydroxyproline (ligand 14a)

Summary for 6GFY

Entry DOI	10.2210/pdb6gfy/pdb
Descriptor	Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (5 entities in total)
Functional Keywords	protein complex, ubiquitin ligase, hypoxia inducible factor, fluorinated hydroxyproline, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	168911.41
Authors	Gadd, M.S.,Testa, A.,Ciulli, A. (deposition date: 2018-05-02, release date: 2018-07-11, Last modification date: 2024-01-17)
Primary citation	Testa, A.,Lucas, X.,Castro, G.V.,Chan, K.H.,Wright, J.E.,Runcie, A.C.,Gadd, M.S.,Harrison, W.T.A.,Ko, E.J.,Fletcher, D.,Ciulli, A. 3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation. J. Am. Chem. Soc., 140:9299-9313, 2018 Cited by PubMed: 29949369 DOI: 10.1021/jacs.8b05807 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation